Is “no test is better than a bad test”? Impact of diagnostic uncertainty in mass testing on the spread of COVID-19"어떤 테스트도 나쁜 테스트보다 낫다"는 말입니까? COVID-19의 확산에 대한 대량 테스트의 진단 불확실성의 영향Research Article Published on 2020-10-212022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] accumulate active viral infection Analysis approach Characteristics country Critical diagnostic dialogue Epidemics False negative false negatives False positive False positives Government immunity passport Impact implication Infection lockdown magnitude Mass screening Measures Misdiagnosis population at risk pressure Prevalence progression risk shown solution spread of COVID-19 suppress Testing the epidemic Viral viral infection virus [DOI] 10.1371/journal.pone.0240775 PMC 바로가기 [Article Type] Research Article
The implementation of a rapid sample preparation method for the detection of SARS-CoV-2 in a diagnostic laboratory in South Africa남아프리카 공화국의 진단 실험실에서 SARS-CoV-2 검출을 위한 신속한 시료 준비 방법 구현Research Article Published on 2020-10-202022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI adopted Cape centrifugation Critical diagnostic downstream equipment evaluated handling Heating implementation Isolation Laboratory nucleic acid Nucleic acid purification positive public health measure public health measures reagent reagents RT-PCR SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 RT-PCR South Africa strained supply chains town Virology [DOI] 10.1371/journal.pone.0241029 PMC 바로가기 [Article Type] Research Article
Development of a multivariate prediction model of intensive care unit transfer or death: A French prospective cohort study of hospitalized COVID-19 patients중환자실 이송 또는 사망의 다변수 예측 모델 개발: 입원한 COVID-19 환자에 대한 프랑스 전향 코호트 연구Research Article Published on 2020-10-192022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 9-point ordinal scale 95% CI acute respiratory syndrome Admission age C-index calibration calibration curve Care Chain Reaction clinical clinical scale cohort study coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient death defined Department development discharge discrimination European population evaluated Factor France French Health Organization hospital Hospitalized hospitalized COVID-19 patient ICU identify increased risk intensive care intensive care unit internal internal medicine laboratory-confirmed lymphocyte Lymphocytes management Medicine moderate multivariable logistic regression multivariable logistic regression models Older age Ordinal Scale outcome Paris Patient patients patients hospitalized positive predicted Probability Prognostic factor Prognostic factors prospective cohort study R 2 respiratory reverse transcriptase risk scoring system single-center transfer university hospital Ventilation was performed were assessed WHO World Health Organization [DOI] 10.1371/journal.pone.0240711 PMC 바로가기 [Article Type] Research Article
Design of novel multiepitope constructs-based peptide vaccine against the structural S, N and M proteins of human COVID-19 using immunoinformatics analysis면역정보학 분석을 이용한 인간 코로나19의 구조적 S, N, M 단백질에 대한 새로운 다중 에피토프 구조 기반 펩타이드 백신 설계Research Article Published on 2020-10-152022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] 3D structure acute respiratory syndrome adopted allergen Analysis analyzed approach B-cell B-cell epitope B-cell epitopes BepiPred Betacoronavirus binding calculated candidate Candidates causative agent cellular immune responses center China CDC Chinese clade cleavage contribute Control Coronaviridae Coverage COVID-19 CTL CTL epitope demonstrated develop disease control domain Efficiency elicit Ellipro epitope Epitopes GalexyPepDock highest HTL HTL epitopes humoral Hypothesis I-TASSER identify IEDB immune responses immunodominant immunoinformatics in silico in vivo Interaction linear MHC multiepitope vaccine N and M NCBI database NetCTL NetMHCpan novel Betacoronavirus peptide predicted proteasomal Protein RBD Receptor-binding domain regions reported respiratory S protein S, N and M proteins SARS-CoV-2 SARS-CoV-2 peptide vaccine SARS-CoV-2 susceptibility sequence Severe acute respiratory syndrome strong interactions Tap transport/proteasomal cleavage These data TLR TLRs TLRs 2, 3 and 4 Transport Vaccination strategies Vaccine virus was obtained [DOI] 10.1371/journal.pone.0240577 PMC 바로가기 [Article Type] Research Article
Potential bioactive glycosylated flavonoids as SARS-CoV-2 main protease inhibitors: A molecular docking and simulation studiesSARS-CoV-2 주요 프로테아제 억제제로서의 잠재적 생체 활성 글리코실화 플라보노이드: 분자 도킹 및 시뮬레이션 연구Research Article Published on 2020-10-152022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, [키워드] 3CL pro 6LU7 Acute respiratory infection antiviral molecules approach AutoDock AutoDock vina best binding affinity chemical structures Chymotrypsin-like protease complex Consensus coronavirus docking experiments Docking studies docking study downloaded drug drug treatment evaluate flavonoids flavonoids chemical structure flavonoids chemical structures fruit glycosylated flavonoid glycosylated flavonoids glycosylated forms highest binding affinity in vitro in vivo experiment inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 investigated limit MD simulation MD simulations molecular docking Molecular docking study natural phenolic compound natural phenolic compounds Novel coronavirus performed Perspective physiological activities plants Potential protease Protein Protein Data Bank Protein Data Bank site PubChem quercetin Quercetin-3-O-rhamnoside respiratory respiratory infection responsible rutin SARS-CoV SARS-CoV-2 main protease SARS-CoV-2 protease Simulation study Spread stability tested the SARS-CoV-2 Treatment virus virus expansion was performed [DOI] 10.1371/journal.pone.0240653 PMC 바로가기 [Article Type] Research Article
Antibody responses to SARS-CoV-2 in patients with differing severities of coronavirus disease 20192019년 코로나바이러스 질병의 중증도가 다른 환자의 SARS-CoV-2에 대한 항체 반응Research Article Published on 2020-10-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI analyzed Antibody Response Antigen association clinical manifestations collected coronavirus disease COVID-19 Cutoff ELISA enrolled enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Euroimmun female greater healthy control IgA IgG IgG antibodies IgG antibody infections male Mild moderate onset of symptom onset of symptoms optical optical density other respiratory infections participant Patient patient group patients positive result respiratory respiratory infections Result SARS-CoV-2 SARS-CoV-2 infections sensitivity serological response serological test severe group severity Severity of disease Severity of infection Sex significantly higher Symptom the antibody response the patient the SARS-CoV-2 vaccination was performed [DOI] 10.1371/journal.pone.0240502 PMC 바로가기 [Article Type] Research Article
In-hospital mortality is associated with inflammatory response in NAFLD patients admitted for COVID-19병원 내 사망률은 COVID-19로 입원한 NAFLD 환자의 염증 반응과 관련이 있습니다Research Article Published on 2020-10-082022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] Admission adverse outcomes C reactive protein cirrhosis clinical Clinical characteristics Clinical data Clinical endpoints clinical outcomes Cohort college consecutive patient COVID-19 CRP Diagnosis died discharged disease disease stage early weaning score Endpoint Evidence EWS Fatty liver fatty liver disease ferritin FIB-4 fibrosis Fibrosis-4 Gender hospital hospitalised Imperial College Healthcare NHS Trust in-hospital mortality Inflammatory response intensive care intensive care unit liver Liver cirrhosis male medical history metabolic risk factor metabolic risk factors Mortality NAFLD NAFLD patient NAFLD patients NHS nine Non-alcoholic fatty liver disease non-NAFLD on admission outcome past medical history Patient Result risk severe COVID-19 significantly stratified Trust were recorded [DOI] 10.1371/journal.pone.0240400 PMC 바로가기 [Article Type] Research Article
Therapeutic effects of adenosine in high flow 21% oxygen aereosol in patients with Covid19-pneumonia코비드19-폐렴 환자의 고유량 21% 산소 에어로졸에서 아데노신의 치료 효과Research Article Published on 2020-10-082022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 24 hour 24 hours active treatments adenosine agonist Analysis ARDS bronchospasm change clinical trials control group controlled clinical trials death demonstrated Effect enrolled experimental group feature hemodynamic historical control Hospitalized Infection Inflammatory inflammatory lung disease Inhaled interstitial lack lung Lung disease Lung inflammation mice Mitigation moderate outcome oxygen oxygenated PaO Patient patients treated preclinical studies preclinical study radiological receive receiving receptor recorded reported Result SARS-CoV-2 RNA SARS-CoV2 infection severe lung inflammation severity significant increase syndrome the disease therapeutic effect Treatment Trigger Ventilation were recorded [DOI] 10.1371/journal.pone.0239692 PMC 바로가기 [Article Type] Research Article
Biochemical screening for SARS-CoV-2 main protease inhibitorsSARS-CoV-2 주요 프로테아제 억제제에 대한 생화학적 스크리닝Research Article Published on 2020-10-062022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] Acetate antiviral drug Benzophenone biochemical Compound Corona cysteine cysteine protease derivative drugs Evan Evans blue expressed fluorescent host cell host cells identify inhibitor inhibitors inhibitors of SARS-CoV-2 lead M pro non-structural proteins pandemic performed phenylmercuric acetate polymerases polyproteins precursor protease Proteases replicate respiratory SARS-CoV M SARS-CoV-2 SARS-CoV-2 main protease Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus sulfonic acid target thimerosal virus was used [DOI] 10.1371/journal.pone.0240079 PMC 바로가기 [Article Type] Research Article
Direct RT-qPCR detection of SARS-CoV-2 RNA from patient nasopharyngeal swabs without an RNA extraction stepRNA 추출 단계 없이 환자 비인두 면봉에서 SARS-CoV-2 RNA의 직접적인 RT-qPCR 검출Methods and Resources Published on 2020-10-022022-08-13 Journal: PLoS Biology [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] approach be positive blinded caused Chain Reaction choke points COVID-19 pandemic COVID-19 testing demonstrated detect determine diagnostic diagnostic testing Direct direct method expand followed by Health Organization include individual infectious Infectious virus nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Patient polymerase chain polymerase chain reaction positive purified RNA extraction RNA extraction kit RNA extraction kits RT-qPCR SARS-CoV-2 RNA sensitivity Swab Viral Viral load viral loads WHO World Health Organization [DOI] 10.1371/journal.pbio.3000896 PMC 바로가기 [Article Type] Methods and Resources