In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine stormIn-silico 약물 용도 변경 연구는 SARS-CoV-2 감염 진행 및 사이토카인 폭풍으로 인한 호흡 곤란을 줄이기 위한 유망한 후보 요법으로 피르페니돈과 멜라토닌의 조합을 예측합니다Research Article Published on 2020-10-022022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] Acute kidney injury acute respiratory syndrome alternative method approach approaches cardiac injury caused Combination contribute COVID-19 COVID-19 treatment Cytokine storm distress drug drug combination drug target drugs GUILDify v2.0 GUILDify v2.0 web server human protein human proteins in some infected patient infected patients Infection infection cycle Injury melatonin multiorgan failure non-severe symptomatic patient non-severe symptomatic patients pathology Patient Pirfenidone potential COVID-19 treatments predict predicted producing progression pulmonary complications reduce respiratory respiratory symptom respiratory symptoms risk Safe SARS-CoV-2 SARS-COV-2 infection Sepsis Septic shock Severe acute respiratory syndrome stage II Standard of care starting System biology the disease therapeutic effect therapy Treatment treatments for COVID-19 virus virus infection web server [DOI] 10.1371/journal.pone.0240149 PMC 바로가기 [Article Type] Research Article
In-silico design of a potential inhibitor of SARS-CoV-2 S proteinSARS-CoV-2 S 단백질의 잠재적 억제제의 in-silico 설계Research Article Published on 2020-10-012022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] ACE2 ACE2 binding site angiotensin angiotensin-converting enzyme 2 approach attachment bind binding binding affinity caused Coronavirus infection Docking studies docking study domain glycoprotein homologue human cell inhibitor International molecular pandemic peptide peptides protease Protein public health emergency RBD receptor Receptor binding domain Registered S protein SARS-CoV-2 S protein SARS-CoV-2 virus therapy Treatment Viral viral infection [DOI] 10.1371/journal.pone.0240004 PMC 바로가기 [Article Type] Research Article
Clinical laboratory parameters associated with severe or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis2019년 중증 또는 중대한 신종 코로나바이러스 감염증(COVID-19)과 관련된 임상 실험실 매개변수: 체계적인 검토 및 메타 분석Research Article Published on 2020-10-012022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval Adaptive immune response articles C-reactive protein calculated carried CD4 CD8 T cell cell counts children CINAHL Clinical course clinical laboratory conducted confirmed case confirmed cases coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 cases Critical Critical disease D-dimer data extraction database databases dimer eligible excluded Google Scholar innate immune response interleukin interleukin-6 Laboratory laboratory parameter lymphocyte marker meta-analyses Meta-analysis MMD MONITOR neutrophil neutrophil count notable novel coronavirus disease observational studies observational study Organ failure Other parameter predictor pregnant women proportion random effect relative reported severity systematic review systematic reviews T cell tissue damage troponin troponin I Web of Science [DOI] 10.1371/journal.pone.0239802 PMC 바로가기 [Article Type] Research Article
Seroprevalence of SARS-CoV-2 antibodies in people with an acute loss in their sense of smell and/or taste in a community-based population in London, UK: An observational cohort study영국 런던의 지역 사회 기반 인구에서 후각 및/또는 미각의 급성 상실이 있는 사람들에서 SARS-CoV-2 항체의 혈청 유병률: 관찰 코호트 연구Research Article Published on 2020-10-012022-08-13 Journal: PLoS Medicine [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] (anosmia 95% CI Ability to smell acute loss of smell and/or taste acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Anosmia antibodies antibody associated symptoms Case isolation caused ClinicalTrials Cohort control group coronavirus coronavirus disease Coronavirus disease 2019 cough country COVID-19 COVID-19 associated symptom COVID-19 associated symptoms COVID-19 infection COVID-19 symptom COVID-19–related symptom COVID-19–related symptoms demographics determine develop enrolled evaluated female Fever Frequency General population general population control group Healthcare professional highly specific COVID-19 symptom IgG IgM Immunoglobulin Immunoglobulin G immunoglobulin M individual Infectious disease invited people lack lateral flow immunoassay lateral flow immunoassay test limitation London Loss Loss of Smell loss of smell and taste loss of smell and/or taste loss of taste medical supervision methodology New Observational cohort study online questionnaire online questionnaires other COVID-19 symptoms pandemic participant participants with SARS-CoV-2 population subset prevalent primary care center primary care centers proportion question reduced Registered reported symptom researcher respiratory SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody Self-isolation self-reported nature sense of smell seroconvert Seropositivity Seropositivity for SARS-CoV-2 Seroprevalence severe acute respiratory syndrome Coronavirus smell and taste changes Smell loss specific symptom Symptom Taste taste change taste changes Taste loss telemedicine consultation text took place Treatment treatment of COVID-19 Treatment strategies treatment strategy United Kingdom virus web-based platform [DOI] 10.1371/journal.pmed.1003358 PMC 바로가기 [Article Type] Research Article
Development and external validation of a prediction risk model for short-term mortality among hospitalized U.S. COVID-19 patients: A proposal for the COVID-AID risk tool입원한 미국 COVID-19 환자의 단기 사망률에 대한 예측 위험 모델의 개발 및 외부 검증: COVID-AID 위험 도구에 대한 제안Research Article Published on 2020-09-302022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019 novel coronavirus disease 95%CI Accuracy age analyses arterial pressure assist AUC calibration Caregiver characteristic Cohort coronavirus disease COVID-19 COVID-AID risk tool Data collection develop development discrimination disease External external validation follow-up time Generalizability goodness of fit hospital Hospitalized hospitalized patient hospitalized patients hypoxia Interaction kidney dysfunction limit Massachusetts mean arterial pressure Mortality mortality risk multicenter multicenter retrospective cohort study Multivariable regression New York Novel coronavirus novel coronavirus disease Patient patient age patients hospitalized patients with COVID-19 performed receiver operating characteristic Research resource Result retrospective cohort study retrospective data risk risk factor Risk factors risk stratification selected severity trials univariable validation with COVID-19 [DOI] 10.1371/journal.pone.0239536 PMC 바로가기 [Article Type] Research Article
Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection비타민 D 충분, 혈청 25-하이드록시비타민 D 최소 30ng/mL는 COVID-19 감염 환자의 불리한 임상 결과에 대한 위험 감소Research Article Published on 2020-09-252022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 25-hydroxyvitamin D analyzed association benefit C-reactive protein C-reactive protein (CRP CDC criteria circulating Clinical outcome clinical outcomes Clinical severity confounding factors COVID-19 COVID-19 infection cytokine Cytokine storm General population help hospital hospitalized patient immune function immune response increase in infected with COVID-19 Infection Inflammatory lymphocyte Lymphocytes marker modulate morbidities morbidity Mortality parameter Patient patients patients older patients with COVID-19 reduced risk reducing reduction in Result risk SARS-COV-2 infection serum serum 25-hydroxyvitamin D serum CRP Serum level Severe COVID-19 Infection severity Study design Viral viral infection Vitamin D Vitamin D status vitamin D sufficiency [DOI] 10.1371/journal.pone.0239799 PMC 바로가기 [Article Type] Research Article
Lipoprotein concentrations over time in the intensive care unit COVID-19 patients: Results from the ApoCOVID study중환자실 COVID-19 환자의 시간 경과에 따른 지단백질 농도: ApoCOVID 연구 결과Research Article Published on 2020-09-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Admission Anti-inflammatory antioxidant association Bacterial Bacterial sepsis bacterial superinfection caused change cholesterol clearance Concentration conducted consecutive patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia dead patient decrease Diagnosis functions global pandemic HDL HDL-C HDLs High-density lipoprotein High-density lipoproteins Hospitalization Hospitalized ICU ICU admission ICU patient incidence increase in intensive care LDL cholesterol LDL-C lipopolysaccharides lipoprotein Lipoproteins Low-density lipoprotein low-density lipoproteins Mortality neutralize nonsurvivors outcome outcomes Particle Particles Patient pleiotropic Pneumonia profile Prospective Study reference values reported respiratory Result Sepsis Severe COVID-19 pneumonia statistically significant superinfection survival survivor Transport university hospital VAP Ventilator-associated pneumonia were assessed [DOI] 10.1371/journal.pone.0239573 PMC 바로가기 [Article Type] Research Article
A machine learning algorithm to increase COVID-19 inpatient diagnostic capacityCOVID-19 입원 환자 진단 능력을 높이는 기계 학습 알고리즘Research Article Published on 2020-09-222022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval Algorithm an area bottleneck Chain Reaction collected data Combination COVID-19 develop diagnose diagnostic diagnostic classification emergency room evaluate Final hospital laboratory feature Los Angeles machine learning model Metrics operator PCR testing PCR-based testing polymerase chain polymerase chain reaction receiving SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2 PCR testing sensitivity Seven specificity System tested [DOI] 10.1371/journal.pone.0239474 PMC 바로가기 [Article Type] Research Article
Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)COVID-19 치료를 위한 중재: 메타 분석 및 시험 순차 분석을 통한 살아있는 체계적인 검토(The LIVING Project)Research Article Published on 2020-09-172022-08-13 Journal: PLoS Medicine [Category] Biochemistry, COVID-19, SARS, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus Admission adverse event adverse events aggregate data meta-analyses all age group all age groups all-cause mortality assessment caused certainty certainty of evidence Clinical effect Clinical research Clinical significance clinical trials Cochrane guidelines Comparisons conducted convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients database development Dexamethasone driven by Effect Evidence evidence of experimental intervention Families GRADE high risk Hydroxychloroquine individual patient data meta-analyses individuals Infection intensive care International Intervention Intervention effects item Juul lack life Lopinavir Lopinavir–ritonavir mechanical ventilation meta-analyses Meta-analysis Network meta-analysis no effect no effects no evidence of nonserious adverse event nonserious adverse events on mechanical ventilation outbreak outcome outcomes participant Participants Patient patient data paucity of data performed Placebo Primary outcomes Quality of life random errors random-effects meta-analyses randomized clinical trial randomized clinical trials rapidly spreading disease rate ratio reduce reduced reducing Remdesivir renal replacement therapy replacement therapy Reporting Research researcher respiratory Respiratory failure review risk risk of bia risk of death risk ratio Ritonavir SARS-CoV-2 searched secondary Secondary outcomes Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single trial single trial randomizing Sophie Spread standard care statistically significant systematic review systematic reviews Treatment treatment for COVID-19 treatment intervention treatment of COVID-19 treatments for COVID-19 treatments of COVID-19 Trial Trial methodology trial randomizing trial sequential analyses trial sequential analysis website with COVID-19 [DOI] 10.1371/journal.pmed.1003293 PMC 바로가기 [Article Type] Research Article
Evaluation of performance of two SARS-CoV-2 Rapid IgM-IgG combined antibody tests on capillary whole blood samples from the fingertip손끝에서 채취한 모세혈관 전혈 검체에 대한 2개의 SARS-CoV-2 Rapid IgM-IgG 결합 항체 검사의 성능 평가Research Article Published on 2020-09-172022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] (COronaVIrus Disease 2019) acute respiratory syndrome coronavirus 2 Adult patients Antibody test calculated capillary Chain Reaction collected conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic detect diagnostic different time point different time points evaluate False positive Finger prick fingertip France gold gold standard greater hospital IgG and IgM Infectious disease Nasopharyngeal swab nasopharyngeal swab specimen Nasopharyngeal swab specimens observational study occurred onset of symptom Orléans Patient patients POC POC test POC tests point-of-care polymerase chain polymerase chain reaction polymerase chain reaction) positive prospective observational study ranged Rapid Rapid test rapid test kit Rapid tests real-time reverse transcriptase resource respiratory Respiratory disease respiratory syndrome coronavirus 2 responsible Result reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR RT-PCR testing SARS-CoV-2 SARS-CoV-2 virus sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies specificity Symptom symptoms of COVID-19 tested the disease was performed Whole blood whole blood sample [DOI] 10.1371/journal.pone.0237694 PMC 바로가기 [Article Type] Research Article