Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancerRNA 시토신-5 메틸화의 발전: 탐지, 조절 메커니즘, 생물학적 기능 및 암과의 연관성Review Published on 2020-09-142022-08-07 Journal: Biomarker Research [Category] Biochemistry, [키워드] 5-methylcytosine accumulating advance approach biological function Biological functions Cancer cancer pathogenesis cancer treatment catalytic cellular distribution cellular processe Detection techniques disadvantage Disadvantages distribution Epitranscriptome Evidence functional consequence functional consequences mechanism mechanisms Modification molecular mRNAs posttranscriptional modification progression Regulatory RNA RNA methylation RNA modification RNAs rRNA rRNAs single-nucleotide substrates Transcriptome tRNAs tumorigenesis vault RNAs Viral Viral RNA viral RNAs [DOI] 10.1186/s40364-020-00225-0 PMC 바로가기 [Article Type] Review
Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasmaSARS-CoV-2 환자 혈장에서 면역우세 선형 에피토프 식별Research Article Published on 2020-09-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antibody Response biochemical evidence cellular entry consequence coronavirus COVID-19 Critical epitope Epitopes furin identification immunodominant inhibit linear epitope linear epitopes pandemic Patient peptide plasma positive proteolytic public health respiratory S1/S2 S1/S2 cleavage site SARS-CoV-2 Spike protein stability the antibody response the spike protein [DOI] 10.1371/journal.pone.0238089 PMC 바로가기 [Article Type] Research Article
Low high-density lipoprotein level is correlated with the severity of COVID-19 patients: an observational study낮은 고밀도 지단백 수치는 COVID-19 환자의 중증도와 상관관계가 있습니다: 관찰 연구Research Published on 2020-09-072022-08-13 Journal: Lipids in Health and Disease [Category] Biochemistry, COVID-19, SARS, [키워드] 95% CI Admission adopted age age and gender blood lipid blood lipid level blood lipid levels C-reactive protein C-reactive protein (CRP China cholesterol Clinical data coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 adult patients COVID-19 patient COVID-19 patients Cox regression analysis diagnosed elevated enrolled event events Gender HDL-C healthy high-density High-density lipoprotein High-density lipoprotein cholesterol higher risk infected with COVID-19 interquartile range Kaplan-Meier LDL-C lipoprotein cholesterol Lipoproteins Low-density lipoprotein Low-Density Lipoprotein cholesterol male Mann-Whitney test median non-severe patients participant Patient Prognosis proportion RANK Result Retrospective analysis Severe case severe cases severe COVID-19 patient severe COVID-19 patients severity of COVID-19 significantly lower Total cholesterol Triglyceride underlying diseases were used [DOI] 10.1186/s12944-020-01382-9 PMC 바로가기 [Article Type] Research
Observational study of azithromycin in hospitalized patients with COVID-19코로나19로 입원한 환자를 대상으로 한 아지스로마이신 관찰 연구Research Article Published on 2020-09-032022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] 48 hour 48 hours adjusted affected Analysis association Azithromycin azithromycin treatment caused change clinical benefit Cohort cohorts Confusion control patients Cox multivariate model Cox multivariate models Cox regression demonstrated discharge Efficacy Evolution Factors had no hazard ratio hospital Hospital stay hospitalized patient log Lung function multiple therapeutic agent multiple therapeutic agents multivariate Multivariate Cox regression models novel SARS-CoV-2 virus observational study oxygen oxygen saturation Patient patients hospitalized patients treated Primary outcomes Prognostic factors pulmonary disease Result SAFI SAFI ratio SARS-CoV-2 virus small sample size Spain Spread study drug the disease therapeutic agents Treatment with COVID-19 [DOI] 10.1371/journal.pone.0238681 PMC 바로가기 [Article Type] Research Article
Comparative genome analysis of novel coronavirus (SARS-CoV-2) from different geographical locations and the effect of mutations on major target proteins: An in silico insight다양한 지리적 위치에서 새로운 코로나바이러스(SARS-CoV-2)의 비교 게놈 분석 및 주요 표적 단백질에 대한 돌연변이의 영향: In silico 통찰력Research Article Published on 2020-09-032022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, SARS, [키워드] active site acute respiratory syndrome Affect affecting Analysis analyzed binding binding affinity carried Characteristics Comparative Complete coronavirus Coronavirus-2 country COVID-19 pandemic COVID19 envelope protein feature Genome genome sequence geographical location geographical locations humans identify identity implication in silico in silico approaches include information inhibitor inhibitors investigated major coronavirus manuscript molecular MPro Mutation Novel coronavirus nucleocapsid protein performed polyprotein protease Protein provided reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes South Korea Spain specific mutation spike glycoprotein Spike protein Spread the binding affinity the SARS-CoV-2 genome the spike protein therapeutic target unique Vaccine Viral viral genome while [DOI] 10.1371/journal.pone.0238344 PMC 바로가기 [Article Type] Research Article
Kidney function on admission predicts in-hospital mortality in COVID-19입원 시 신장 기능, COVID-19에서 병원 내 사망률 예측Research Article Published on 2020-09-032022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] Acute kidney injury Admission Analysis association baseline Binary logistic regression calculated Care collected consecutive patient COVID-19 COVID-19 prognosis Cox regression Cox regression analysis criteria defined diagnosis of COVID-19 EGFR Electronic health record Electronic health records Follow-up hospital Hospitalized in-hospital mortality in-hospital mortality rate KDIGO Kidney function Kidney injury Logistic regression analysis male Mortality mortality rate multivariate logistic regression occurred Odds ratio on admission Patient patients patients with COVID-19 predict Prognostic marker recent recruited reduced Result risk stratification suggested university hospital were used [DOI] 10.1371/journal.pone.0238680 PMC 바로가기 [Article Type] Research Article
A meta-analysis of potential biomarkers associated with severity of coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 심각성과 관련된 잠재적 바이오마커의 메타 분석Review Published on 2020-08-312022-08-07 Journal: Biomarker Research [Category] Biochemistry, COVID-19, [키워드] (lymphocyte (procalcitonin 95%CI albuminemia association available data Bilirubin biochemical Biochemical parameters Biomarker Biomarkers Blood level Blood urea nitrogen C-reactive protein CK-MB coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case Creatininemia CRP D-dimer effect sizes elevated eosinophil eosinophils Factor haematologic Haemoglobin help hematological higher risk identify Inflammatory interleukin interleukin-6 LDH lymphocyte Lymphocyte count Lymphocytes lymphopenia Meta-analysis Myoglobin nitrogen opposition P-value patients with COVID-19 Potential biomarker procalcitonin procalcitonin level Prognostic biomarkers prognostic risk stratification proportion Protein prothrombin Prothrombin time Random-effects meta-analysis Result retained searched severe cases severe COVID-19 Severe patient severe patients severity severity of COVID-19 significantly significantly lower significantly more SMD standardized mean difference thrombocyte Thrombocytes thrombocytopenia total bilirubin troponin troponin I urea was used Web γ-GT PMC 바로가기 [Article Type] Review
Prevalence of pulmonary embolism in patients with COVID-19 pneumonia and high D-dimer values: A prospective studyCOVID-19 폐렴 및 높은 D-dimer 값을 가진 환자에서 폐색전증의 유병률: 전향적 연구Research Article Published on 2020-08-252022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] abnormal coagulation Administered analysed anticoagulant therapy C reactive protein C reactive protein values Clinical outcome clinical outcomes clinical suspicion clinically suspected Coagulation Comorbidities Computed tomography Computed tomography pulmonary angiography confirmed case consecutive patient contribute coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pneumonia CTPA D-dimer D-dimer elevation D-dimer value D-dimer values demographic diagnose diagnosed diagnoses disease severity emboli IMPROVE in-hospital mortality IQR laboratory data magnitude material median age non-PE non-PE group not differ Older Patient patients with COVID-19 patients with PE PE patients Platelet Platelet count Pneumonia Prevalence Prognosis prognosis of patient prospective cohort study Prospective Study pulmonary angiography Pulmonary embolism radiologic magnitude Result Retrospective study risk factor segmental arteries segmental artery Sex significantly significantly higher systemic hyper-inflammation thromboembolic thromboembolic disease with COVID-19 women [DOI] 10.1371/journal.pone.0238216 PMC 바로가기 [Article Type] Research Article
COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2COVID-19 전염병: SARS-CoV-2에 의한 구조, 기능 및 hACE2 수용체 인식에 대한 통찰력Review Published on 2020-08-212022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, MERS, [키워드] (RdRp ACE2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antigenicity caused cell membrane Characteristics Comparative analysis conformational change coronavirus Coronaviruses COVID-19 Critical Cross-species transmission death determinant Drug discovery Evolution of SARS-CoV-2 explain Factors fusion global public health glycoprotein hACE2 receptor host cell host range Human human cells Infection initiate insight knowledge mechanism pathogenic coronavirus RBD RdRP receptor Receptor-binding domain recognize reported respiratory RNA-dependent RNA polymerase S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 S protein Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 specificity the receptor-binding domain the S protein Vaccine Viral viral entry viral infection viral infections virus [DOI] 10.1371/journal.ppat.1008762 PMC 바로가기 [Article Type] Review
Tocilizumab and steroid treatment in patients with COVID-19 pneumonia코로나19 폐렴 환자에서 토실리주맙과 스테로이드 치료Research Article Published on 2020-08-202022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 95%CI adjusted age analyses anti-inflammatory treatment Comorbidities Comorbidity controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia Cox regression analysis darunavir death defined determine difference early treatment Efficacy Endpoint endpoints Evidence failure group hazard hazard ratio Hospital admission Hydroxychloroquine immune response IMPROVE intravenously Intubated intubation IQR lead male median median age Methylprednisolone non-intubated patient non-intubated patients not intubated outcome overall survival PaO Patient patients with COVID-19 Pneumonia primary endpoint Propensity score Ratio Respiratory failure Result Ritonavir Severe COVID-19 pneumonia single-center study Standard of care steroid steroid treatment Steroids subcutaneously survival Tocilizumab treated patient Treatment treatment with tocilizumab with COVID-19 [DOI] 10.1371/journal.pone.0237831 PMC 바로가기 [Article Type] Research Article