High seroprevalence for SARS-CoV-2 among household members of essential workers detected using a dried blood spot assay건조 혈반 분석을 통해 검출된 필수 근로자의 가구 구성원 중 SARS-CoV-2에 대한 높은 혈청 유병률Research Article Published on 2020-08-142022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] acute COVID-19 Analysis antibody Antibody responses Blood blood collection clinical setting clinical settings collected Community community settings convalescent COVID-19 COVID-19 case DBS sample DBS samples diagnoses ELISA epidemiological essential worker facilitate feasible Filter Paper finger Health care health care workers household IgG antibodies IgG antibody individual Infection limit MONITOR objective participant provide Receptor binding domain Reinfection responses Result Sample SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody SARS-CoV-2 spike protein Seroconversion serological test Serological testing seropositive serum/plasma Spike protein stick the SARS-CoV-2 the spike protein Transmission transmission of SARS-CoV-2 utility venous venous blood Whole blood [DOI] 10.1371/journal.pone.0237833 PMC 바로가기 [Article Type] Research Article
Structural insight into the role of novel SARS-CoV-2 E protein: A potential target for vaccine development and other therapeutic strategies새로운 SARS-CoV-2 E 단백질의 역할에 대한 구조적 통찰력: 백신 개발 및 기타 치료 전략의 잠재적 표적Research Article Published on 2020-08-122022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] addition approach ASN bioinformatics channel channeling conserved COVID-19 Critical docking Drug development E protein envelope ERGIC GLU H-bond H-bonds homology hydrophobic in viral Infection insertion ion channel ions mechanism membrane MOST mutability N-terminal N-terminus outbreak Pathogenesis protease provide regions regulate SARS-CoV-2 sequence similarity Spike proteins Structure the spike protein the vaccine therapeutic intervention therapeutic interventions therapeutic strategy Vaccine development Viral viral infection viral replication virus water [DOI] 10.1371/journal.pone.0237300 PMC 바로가기 [Article Type] Research Article
Global cataloguing of variations in untranslated regions of viral genome and prediction of key host RNA binding protein-microRNA interactions modulating genome stability in SARS-CoV-2바이러스 게놈의 번역되지 않은 영역의 변이에 대한 글로벌 카탈로그 및 SARS-CoV-2에서 게놈 안정성을 조절하는 주요 숙주 RNA 결합 단백질-마이크로RNA 상호작용 예측Research Article Published on 2020-08-112022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 3’-UTR aligned Anti-viral binding binding site caused changes in checked Clustal Omega coding region Complete Compound Consequences coronavirus COVID-19 pandemic Critical cross-talk cut-off downloaded effort explain FASTA format Genome genomic change geographical regions GISAID global change Host human coronavirus human host idea identify Infection Influenza initiative Interaction investigated knowledge lung mechanism microRNA MicroRNAs miRNAs modulating phenomenon Region regions Regulation Result RNA RNA binding protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-COV-2 infection selected sequence information stability tissue unique untranslated regions UTR variant variants Variation variations Viral viral genome viral RNA genome virus [DOI] 10.1371/journal.pone.0237559 PMC 바로가기 [Article Type] Research Article
Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domainACE2-Fc 융합 단백질의 완전히 당화된 분자 모델의 개발 및 시뮬레이션 및 SARS-CoV-2 스파이크 단백질 결합 도메인과의 상호 작용Research Article Published on 2020-08-052022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor ACE2-Fc Algorithm Algorithms binding domain conformation COVID-19 develop development fragment fragment of fusion protein glycan glycans glycosylated glycosylation Interaction molecular molecular dynamics Protein RBD Receptor-binding domain SARS-CoV-2 virus Spike protein Spike Protein S target targets tested the receptor-binding domain the SARS-CoV-2 the SARS-CoV-2 virus the Spike therapeutic [DOI] 10.1371/journal.pone.0237295 PMC 바로가기 [Article Type] Research Article
Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2miRNA 및 mRNA 시퀀싱 데이터의 통합 분석은 ACE2 및 TMPRSS2의 잠재적인 조절 메커니즘을 보여줍니다Research Article Published on 2020-07-292022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] ACE2 Affect Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach Atla Cell COVID-19 pandemic demethylase development enzyme Enzymes expression Genes increasingly Infection isoform isomiR JARID1B KDM5B lysine mechanism miRNA mRNA multiple tissues organ Regulation Regulatory reveal searched sequencing data Serine TMPRSS2 TMPRSS2 expression Transcription transmembrane serine protease transmembrane serine protease 2 [DOI] 10.1371/journal.pone.0235987 PMC 바로가기 [Article Type] Research Article
Developing a low-cost and accessible COVID-19 vaccine for global health전 세계 건강을 위한 저렴하고 접근 가능한 COVID-19 백신 개발Viewpoints Published on 2020-07-292022-08-13 Journal: PLoS Neglected Tropical Diseases [Category] Biochemistry, COVID-19, SARS, [키워드] COVID-19 vaccine Developing Health [DOI] 10.1371/journal.pntd.0008548 PMC 바로가기 [Article Type] Viewpoints
Detection of SARS-CoV-2 RNA by direct RT-qPCR on nasopharyngeal specimens without extraction of viral RNA바이러스 RNA를 추출하지 않고 비인두 표본에서 직접 RT-qPCR에 의한 SARS-CoV-2 RNA 검출Research Article Published on 2020-07-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] Accuracy analytical sensitivity approach circumvent collected condition demonstrated detect detection develop direct approach expand help Incubation Laboratory limit of detection master mix medium nasopharyngeal specimen Nasopharyngeal swab nasopharyngeal swabs other conditions other coronavirus other coronaviruses PCR Pearson correlation coefficient positive positively correlated protocol provide reagents reproducibility resource RNA extraction RT-qPCR RT-qPCR assay RT-qPCR assays RT-qPCR master mixes SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 testing sensitivity specificity specimen submitted TaqPath tested Transport Variation Viral Viral RNA virus [DOI] 10.1371/journal.pone.0236564 PMC 바로가기 [Article Type] Research Article
In silico identification of potential inhibitors of key SARS-CoV-2 3CL hydrolase (Mpro) via molecular docking, MMGBSA predictive binding energy calculations, and molecular dynamics simulation분자 도킹, MMGBSA 예측 결합 에너지 계산 및 분자 역학 시뮬레이션을 통한 주요 SARS-CoV-2 3CL 가수분해효소(Mpro)의 잠재적 억제제의 실리코 식별Research Article Published on 2020-07-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] 3CL hydrolase 6LU7 analyzed antiviral drug binding binding energy Biological center Chemical complex Compound compounds Course Critical crystal structure develop docking docking scores drug therapy Dynamics effective effort exhibited highest house hydrolase in silico in viral incidence inhibitor inhibitors of SARS-CoV-2 Karachi Ligand medical emergency molecular molecular docking molecular dynamics Molecular dynamics simulation MPro nine novel corona virus PDB PDB ID predicted Predictive protease Protease inhibitor Replication reported SARS-CoV-2 SARS-CoV-2 main protease screened simulation studies stability the disease the vaccine therapy Treatment university Viral viral replication while [DOI] 10.1371/journal.pone.0235030 PMC 바로가기 [Article Type] Research Article
Clinical characteristics of 82 cases of death from COVID-19코로나19 사망자 82명의 임상적 특징Research Article Published on 2020-07-092022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] Admission age Alanine alanine aminotransferase aspartate Aspartate aminotransferase association C-reactive protein Cancer cardiac failure cause of death caused Cerebrovascular disease Characteristics clinical Clinical characteristics Clinical data Comorbidities Comorbidity COVID-19 cytokine cytokine release Cytokine release syndrome D-dimer Data collection death death case detected patients develop diabete diabetes diagnosed died disease electronic medical record followed by forms heart disease hemorrhage Hemorrhagic hemorrhagic damage hypertension ICU IL-6 initial symptom initial symptoms IQR laboratory-confirmed Lactate lactate dehydrogenase Local lymphocyte lymphopenia male mechanical ventilation support median age median time medical records MOST Most patient Most patients neutrophil Neutrophil-to-lymphocyte ratio neutrophilia Older on admission other organs oxygen Patient patients Pneumonia proportion remained renal renal damage renal failure respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection Sepsis severe disease single center Spread systemic immune-inflammation index the median the patient thrombocytopenia treated virus Wuhan Wuhan local hospital’ Wuhan, China [DOI] 10.1371/journal.pone.0235458 PMC 바로가기 [Article Type] Research Article
Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structureSARS-CoV-2의 RNA 의존성 RNA 중합효소의 새로운 돌연변이 식별 및 단백질 구조에 미치는 영향Biochemistry Published on 2020-07-032022-08-13 Journal: PeerJ [Category] Biochemistry, COVID-19, [키워드] (RdRp Alter alteration Analysis antigenic antivirals COVID-19 pandemic develop drug resistance duplication effective evade functional consequence functional consequences Genome Health high mutation rate highlighting host immunity identification identify implication Indian geographical area interfere isolate Mutation mutation rate Nsp12 Occurrence pharmacological agents Protein RdRP RdRp mutation RdRp mutations RdRp protein RdRp sequence RdRp sequences RNA synthesis RNA virus RNA-dependent RNA polymerase RNA-dependent RNA polymerases (RdRp) SARS-CoV-2 SARS-CoV-2 isolate secondary structure secondary structure prediction analysis sequence Seven shifting stability the SARS-CoV-2 Variability Variation Viral viral evolution viral genome Viral RNA Viral RNA-dependent RNA polymerases virus viruses [DOI] 10.7717/peerj.9492 PMC 바로가기 [Article Type] Biochemistry