Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals공통 변이체는 매우 작은 개체를 제외하고 분포 꼬리의 키에 대한 예측된 다유전자 효과를 보여줍니다Research Article Published on 2011-12-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major allele Author average calculated chance classic cohorts common common disease common variants complex decrease determine discrepancy distribution Effect effect size Effects effort expectation expected explain explained extreme Factor found fraction Frequency Genetic Genetic variant Genetic variation Height Human genome implication include individual individuals less loci low frequency Odds ratio Odds ratios phenotype Phenotypes population-based cohort Predictive quantitative traits short stature show shown significantly stature tail trait traits variant variants Variation whole-exome sequencing whole-genome [DOI] 10.1371/journal.pgen.1002439 PMC 바로가기 [Article Type] Research Article
Identification of a Genomic Reservoir for New TRIM Genes in Primate Genomes영장류 게놈에서 새로운 TRIM 유전자에 대한 게놈 저장소 식별Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] African antiviral gene antiviral genes Author best Biology characterized chromosome chromosome 11 Cluster compared copy number Defense described determine Divergence duplication duplications Evolution expressed found Gene gene cluster Genes Genome genomes Han Chinese HIV Human Human genome human population identification immune system individual innate immune response innate immune system Innate immunity locus majority mechanism MOST natural selection neutralized New pathogen Pathogens positive primate primates question Region reservoir restrict restriction factor retroviral rhesus macaques screened selected Specificities target specificity Tripartite Motif ubiquitin ligase virus recognition viruses young gene [DOI] 10.1371/journal.pgen.1002388 PMC 바로가기 [Article Type] Research Article
SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatusSREBP는 인간 곰팡이 병원체 Aspergillus fumigatus에서 트리아졸 약물 및 저산소증 반응을 중재하기 위해 철과 에르고스테롤 항상성을 조정합니다Research Article Published on 2011-12-012022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A. fumigatus acquisition activated adaptation Adding addition advance Aspergillus fumigatus Author binding Candida albican Candida albicans caused cellular response class clinically condition conditions Coordinate Critical Cryptococcus neoforman Cryptococcus neoformans decrease dependent on drug drug susceptibility drugs ergosterol eukaryotes found foundation fungal fungal infections fungal pathogen Gene Genetic growth growth defect Health Human hypoxia hypoxic identify immunocompromised condition infections initial involved iron iron homeostasis Iron metabolism led to lethal disease majority mechanism metabolism microenvironment Most patients mRNA mutant mutants pathogenic Pathogens Patient phenotype Protein regulate Regulation regulatory element required response restoration Sterol Support susceptibility susceptible These data transcription factor transcription factors triazole virulence [DOI] 10.1371/journal.pgen.1002374 PMC 바로가기 [Article Type] Research Article
Role of Exonic Variation in Chemokine Receptor Genes on AIDS: CCRL2 F167Y Association with Pneumocystis PneumoniaAIDS에 대한 케모카인 수용체 유전자의 외음성 변이의 역할: 폐포자충과의 CCRL2 F167Y 연관성Research Article Published on 2011-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 95% CI accelerated addition Affect AIDS Amino acid analysis Analysis association associations Atypical Author CCR2 CCR3 CCR5 CCR8 CCRL2 Cell Chemokine receptor chromosome Cluster cohorts conditions CX3CR1 defined dendritic cell disease Disease progression DNA Effect exonic FIVE functional variant functional variants Gene Genes Genetic genetic association Genetic variation genotyped HIV-1 HIV-1 infection host cells Human immune regulation in addition to indicated Inflammation involved key factor lung majority natural history Non-synonymous outcome Pathogenesis Pneumonia progression role Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs surface protein survival survival analysis tested variant Variation [DOI] 10.1371/journal.pgen.1002328 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol상호 작용을 위한 게놈 와이드 스크린은 총 콜레스테롤에 대한 허리 대 엉덩이 비율의 영향을 수정하는 4p15에 대한 새로운 위치를 밝힙니다.Research Article Published on 2011-10-202022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] A allele adipose Adipose tissue affected affecting allele approach association Author body composition candidate gene cardiovascular diseases CCKAR characterized cholesterol chromosome circulating Cohort collected Concentration conducted contribute dataset demonstrated described differential expression distribution Effect enrichment epidemiological European explain found functions G allele Gene Gene Expression Genetic variant genome-wide association genome-wide significant genomic Genotype genotypes global health GWA Health heritability homozygous identify individual initial Interaction Intervention joint Lipid lipid metabolism lipids loci locus Low-density lipoprotein Low-Density Lipoprotein cholesterol measure Meta-analysis metabolism modify Modifying New open PCDH7 Phenotypes population-based cohort profiles Ratio recent related Replication reported risk risk factor Risk factors Screen screened serum serum lipid Serum lipids Sex Standard deviation tissue Total Total cholesterol Triglyceride triglycerides variant variants waist waist-to-hip ratio WHR [DOI] 10.1371/journal.pgen.1002333 PMC 바로가기 [Article Type] Research Article
A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci6개의 1형 당뇨병 코호트에 대한 게놈 전체 메타 분석으로 여러 관련 유전자좌 식별Research Article Published on 2011-09-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ADCY3 affected association Author C6orf120 CENPO chromosomal combined cohort contributing to controls dataset diabete diabetes disease DLL1 DNAJC27 DNMT3A domain EFR3B examined excess FAM120B Follow-up Gene gene network gene networks Genes Genetic genetic component genetic loci genetic screening Genome Genome-wide association studies Genome-wide association study genome-wide significance genotyped GWAS homolog hypotheses identify Impact independent intergenic region intronic region investigator investigators Linkage disequilibrium LMO7 LOC154449 loci meta-analyses Meta-analysis Multiple NCOA1 Pathogenesis PHF10 POMC Protein PSMB1 reached recent finding Region replicated risk risk for disease significantly SNP SNPs susceptibility T1D TBP the disease Type Type 1 diabetes variant variants WDR27 [DOI] 10.1371/journal.pgen.1002293 PMC 바로가기 [Article Type] Research Article
Large-Scale Gene-Centric Analysis Identifies Novel Variants for Coronary Artery Disease대규모 유전자 중심 분석으로 관상동맥 질환에 대한 새로운 변종 식별Research Article Published on 2011-09-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] ABCG5 ABCG8 aetiology Affect allele Analysis array Artery Asians association association tests Author biochemical CAD candidate gene cardiovascular disease cellular characterized COL4A1 COL4A2 common variants complement conducted Control controls Coronary Coronary artery Coronary artery disease custom-designed array customised gene array CYP17A1 disease Effect European Europeans Evidence evidence of examined except for found Frequency function functional variant functional variants Gene Gene Expression Genes Genetic Genetic variant genome-wide association genotyped GWA heart disease help heterogeneity identify IL5 LIPA loci low frequency LPA majority mechanism not differ novel novel association novel associations Odds ratio Potential potential mechanism potential mechanisms replicate Replication reported risk risk factor South South Asian suggested supported susceptibility susceptibility loci target tested therapeutic interventions TRIB1 variant variants Vascular ZC3HC1 [DOI] 10.1371/journal.pgen.1002260 PMC 바로가기 [Article Type] Research Article
Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence주요 대립 유전자 참조 서열을 사용한 가족 4중주에서의 단계적 전체 게놈 유전적 위험Research Article Published on 2011-09-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy allele Analysis approach Author base pairs base pairs) Blood blood clot characterization coding compound heterozygosity contribute contributing to demonstrated develop disease disease risk disease-associated estimation facilitate family Gene genetic determinant genetic determinants genetic information genetic profile genetic risk genetic risk factor genetic risk factors Genetic variation Genome genomes Genotype Haplotype Human human leukocyte antigen identify Interpretation leukocyte loci lowest lung Major median medications methodology nuclear nuclear family occur pharmacological predisposition Pulmonary embolism quantification Quartet Recombination reference reference sequence risk Risk assessment risk for disease sequence Sequencing sequencing error sequencing errors therapy Thrombophilia variant whole-genome sequencing [DOI] 10.1371/journal.pgen.1002280 PMC 바로가기 [Article Type] Research Article
Comparative and Functional Genomics of Rhodococcus opacus PD630 for Biofuels Development바이오연료 개발을 위한 Rhodococcus opacus PD630의 비교 및 기능 유전체학Research Article Published on 2011-09-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accurate Actinomycetale Analysis approach assigned Author Bacteria bacterium Biofuel carbon catabolic cellular Comparative Comparative analysis Complete compounds conserved development dry weight Engineering Enzymes eukaryotic Fatty acid fatty acids Gene gene family Genetic Genome genome sequence Genomics growth homologous homologous genes identify implicated included information led to lipid metabolism metabolic product metabolism multidisciplinary approach Pathways performed phenotypic phenotypic information Phylogenetic analysis predicted gene provide provided reaction related Research screened sequenced substrate substrates Support target gene Target genes triacylglycerol working model [DOI] 10.1371/journal.pgen.1002219 PMC 바로가기 [Article Type] Research Article
MK2-Dependent p38b Signalling Protects Drosophila Hindgut Enterocytes against JNK-Induced Apoptosis under Chronic StressMK2-의존성 p38b 신호는 만성 스트레스 하에서 JNK 유도 세포자멸사로부터 Drosophila Hindgut Enterocytes를 보호합니다Research Article Published on 2011-08-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence addressed affected antimicrobial peptides Apoptosis atrophy Author branch cascade Cell chronic complex component contribute damage damaged descendants Deterioration Diseases Drosophila Elimination Enterocyte enterocytes epithelial epithelium event form genetic analysis Gut Hindgut homeostasis Impaired induce integrity intestinal Intestinal diseases intestinal epithelium intestinal stem cell Intestinal stem cells JNK kinases leads less manifested pathogen Pathogens pathway peptides peptides) Prevent proliferation PROTECT Protective Protein protein kinase replaced REPLACED BY Replenishment required salt Signal transduction stem cell stem cells Stress Stressor stressors subsequent suppresse Trigger triggers upregulated upstream [DOI] 10.1371/journal.pgen.1002168 PMC 바로가기 [Article Type] Research Article