Abstract
An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.
Keywords: Covid-19; Cytokine storm; IL-6; Immunoglobulins; Plasma cell dyscrasia; Sars-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, IL-6, immunoglobulins, Plasma cell dyscrasia, 【초록키워드】 Cytokine storm, immune response, spike, IL-6, immunoglobulins, cytokine, Spike protein, Protein, Cohort, Viral, Humoral response, plasma, Swab, serological, Plasma cell, Plasma cell dyscrasia, COVID-19 patient, Trigger, humoral, triggers, viral spike protein, Viral antigen, Anomaly, severe COVID-19 patients, positive, Cell, dyscrasia, gammopathy, selected, reported, investigated, the disease, elevated, accompanied, 【제목키워드】 plasma, Plasma cell dyscrasia, COVID-19 patient, triggering, Cell, Transient,