Abstract
Over the last 10 years, the evaluation of the neutrophil-to-lymphocyte ratio (NLR) as an emerging marker of diseases has become a compelling field of bio-medical research. Although a precise and unique cut-off value has not been yet found, its role as a flag of immune system homeostasis is well established. NLR has a well-known prognostic value and independently correlates with mortality in the general population and in several specific subsets of disease (sepsis, pneumonia, COVID-19, cancer, etc.). Moreover, NLR was recently considered as part of the decision-making processes concerning the admission/recovery of patients with COVID-19 pneumonia. This review aims to provide an overview of the main use of this biomarker, focusing on the pathophysiology and the molecular basis underlying its central role as a reliable mirror of inflammatory status and adaptive immunity.
Keywords: coronavirus disease-2019 (COVID-19); intensive care unit (ICU); marker; mortality; neutrophil-to-lymphocyte ratio (NLR); prognosis; sepsis.
【저자키워드】 Mortality, Prognosis, Sepsis, coronavirus disease-2019 (COVID-19), intensive care unit (ICU), marker, neutrophil-to-lymphocyte ratio (NLR), 【초록키워드】 COVID-19, coronavirus disease, Adaptive immunity, coronavirus, COVID-19 pneumonia, Biomarker, adaptive, intensive care, Immunity, Prognosis, Pneumonia, Cancer, neutrophil, intensive care unit, Sepsis, immune system, coronavirus disease-2019, Neutrophil-to-lymphocyte ratio, lymphocyte, pathophysiology, Research, General population, disease, homeostasis, marker, NLR, Prognostic value, molecular basis, cut-off value, inflammatory status, over, FLAG, unique, subset, concerning, patients with COVID-19, 【제목키워드】 System, relationship,