Abstract
Adequate maternal selenium level is essential for immune response and healthy pregnancy. This study aimed to shed light on the selenium status of pregnant women with COVID-19 and the effects of potential deficiency in serum selenium levels. Totally 141 pregnant women, 71 of them were COVID-19 patients, in different trimesters were included in the study. Maternal serum selenium levels, demographic and clinical parameters were determined. Serum selenium levels of pregnant women in the second (p: .0003) and third (p: .001) trimesters with COVID-19 were significantly lower than in the healthy group. Maternal selenium level was found to be negatively correlated with gestational week (p < .0001, r: -.541), D-dimer (p: .0002, r: -.363) and interleukin-6 (IL-6) level (p: .02, r: -.243). In the second trimester, serum selenium level positively correlated with white blood cell (p: .002, r: .424), neutrophil (p: .006, r: .39), lymphocyte (p: .004, r: .410) count and hemoglobin (p: .02, r: .323), hematocrit (p: .008, r: .38) status. In the third trimester, it was found that maternal selenium level positively correlated with monocyte (p: .04, r: .353) and negatively correlated with C-reactive protein level (p: .03, r: -.384). Serum selenium level was gradually decreased during the pregnancy period, however, this natural decrease was enhanced together with COVID-19 infection. The reason might be increased selenium needs depended on the immune response against infection. The decrease in maternal selenium level was found to be related to IL-6 and D-dimer levels, which indicate selenium’s role in disease progression.
Keywords: COVID-19; immunity; infection; pregnancy; selenium.
【저자키워드】 COVID-19, Immunity, Infection, Pregnancy, Selenium, 【초록키워드】 immune response, IL-6, neutrophil, interleukin-6, C-reactive protein, D-dimer, monocyte, pregnant women, Disease progression, lymphocyte, serum, Maternal, Pregnancy, interleukin, White blood cell, COVID-19 infection, Selenium, hemoglobin, COVID-19 patients, hematocrit, Clinical parameters, blood cell, deficiency, second trimester, D-dimer levels, reason, count, significantly lower, clinical parameter, Effect, decrease, healthy, correlated, Adequate, positively correlated, the healthy, with COVID-19, 【제목키워드】 Clinical outcome, Maternal, with COVID-19,