Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 emerged in China in December 2019 and then rapidly spread worldwide. Why COVID-19 patients with the same clinical condition have different outcomes remains unclear. This study aimed to examine the differences in the phenotype and functions of major populations of immune cells between COVID-19 patients with same severity but different outcomes. Four common type adult inpatients with laboratory confirmed COVID-19 from Beijing YouAn Hospital, Capital Medical University were included in this study. The patients were divided into two groups based on whether or not COVID-19 polymerase chain reaction (PCR)-negative conversion occurred within 3 weeks. Peripheral blood samples were collected to compare the differences in the phenotype and functions of major populations of immune cells between the two groups of patients. The result shows that the proportions of CD3 + CD8 + CD38 + HLA-DR + CD27 – effector T killer cells generally declined, whereas that of CD3 + CD4 + CD8 + double-positive T cells (DPTs) increased in the persistently PCR-positive patients. In summary, considering the imbalance between effector T killer cells/CD3+CD4+CD8+ DPTs was a possible key factor for PCR-negative conversion in patients with COVID-19.
Keywords: COVID-19; immune response; nucleic acid conversion.
【저자키워드】 COVID-19, immune response, nucleic acid conversion., 【초록키워드】 coronavirus disease, Coronavirus disease 2019, coronavirus, immune response, T cells, severity, outcome, severe acute respiratory syndrome Coronavirus, CD4, CD8, immune, Population, Laboratory, Peripheral blood, Spread, China, outcomes, polymerase chain reaction, nucleic acid, T cell, Patient, phenotype, immune cells, respiratory, university, patients, HLA-DR, CD38, function, COVID-19 patients, CD27, Immune cell, COVID-19 patient, Chain Reaction, killer cells, Inpatient, Imbalance, Capital, acute respiratory syndrome, two groups, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, proportions, PCR-positive, Beijing, functions, key factor, clinical condition, peripheral blood samples, PCR-negative, CD3, DPT, T killer cells, polymerase chain, collected, occurred, caused, proportion, two group, declined, patients with COVID-19, Peripheral blood sample, T killer cell, 【제목키워드】 Pathogenesis, SARS-COV-2 infection, response, PCR-positive patient,