Abstract
Objectives: To determine the impact of the 32 bp deletion (CCR5Δ32) in the coding region of the C-C chemokine receptor 5 (CCR5) on the risk of contracting SARS-CoV-2 and severe COVID-19.
Methods: Cross-sectional study among stem cell donors registered with DKMS in Germany. Genetic information was linked to self-reported COVID-19 outcome data. Multivariable regression models were fitted to determine the risk of contracting SARS-CoV-2, severe respiratory tract infection (RTI) and respiratory hospitalization.
Results: CCR5 information was available for 110 544 donors who were tested at least once for SARS-CoV-2; 5536 reported SARS-CoV-2 infection. For 4758 donors, the COVID-19 disease course was fully evaluable; 498 reported no symptoms, 1227 described symptoms of severe respiratory tract infection, of whom 164 required respiratory hospitalization. The distribution of CCR5Δ32 genotypes (homozygous wild-type vs CCR5Δ32 present) did not differ significantly between individuals with or without SARS-CoV-2 infection (odds ratio (OR) 0.96, 95% CI 0.89-1.03, P = 0.21) nor between individuals with or without symptomatic infection (OR 1.13, 95% CI 0.88-1.45, P = 0.32), severe RTI (OR 1.03, 95% CI 0.88-1.22, P = 0.68) or respiratory hospitalization (OR 1.16, 95% CI 0.79-1.69, P = 0.45).
Conclusions: Our data implicate that CCR5Δ32 mutations do not determine the risk of SARS-CoV-2 infections nor the disease course.
Trial registration: We registered the study with the German Center for Infection Research (https://dzif.clinicalsite.org/de/cat/2099/trial/4361).
Keywords: CCR5; CCR5Δ32; COVID-19; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, CCR5, CCR5Δ32, 【초록키워드】 SARS-CoV-2, Mutation, severe COVID-19, Hospitalization, SARS-COV-2 infection, respiratory tract infection, risk, Symptom, outcome, COVID-19 disease, cross-sectional study, Germany, Genotype, donors, distribution, information, Chemokine receptor, CCR5, SARS-CoV-2 infections, Donor, symptomatic infection, Odds ratio, stem cell, no symptoms, 95% CI, individual, Multivariable regression, disease course, coding region, Registered, center, wild-type, genetic information, homozygous, multivariable regression models, Cell, COVID-19 disease course, DKMS, Course, not differ, tested, described, significantly, reported, the disease, required, determine, 【제목키워드】 Mutation, determine,