Abstract
Knowledge of the epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targeted by T cells in recovered (convalescent) individuals is important for understanding T cell immunity against coronavirus disease 2019 (COVID-19). This information can aid development and assessment of COVID-19 vaccines and inform novel diagnostic technologies. Here, we provide a unified description and meta-analysis of SARS-CoV-2 T cell epitopes compiled from 18 studies of cohorts of individuals recovered from COVID-19 (852 individuals in total). Our analysis demonstrates the broad diversity of T cell epitopes that have been recorded for SARS-CoV-2. A large majority are seemingly unaffected by current variants of concern. We identify a set of 20 immunoprevalent epitopes that induced T cell responses in multiple cohorts and in a large fraction of tested individuals. The landscape of SARS-CoV-2 T cell epitopes we describe can help guide immunological studies, including those related to vaccines and diagnostics. A web-based platform has been developed to help complement these efforts.
Keywords: CD4; CD8; SARS-CoV-2; T cells; convalescent patients; epitopes; immunodominant epitopes; immunoprevalent epitopes; population coverage; variants of concern.
【저자키워드】 SARS-CoV-2, T cells, variants of concern, CD4, CD8, Epitopes, Convalescent patients, immunodominant epitopes, immunoprevalent epitopes, population coverage, 【초록키워드】 COVID-19, coronavirus disease, Meta-analysis, Coronavirus disease 2019, Vaccine, coronavirus, COVID-19 vaccine, Immunity, T cells, diagnostic, variants of concern, complement, severe acute respiratory syndrome Coronavirus, diagnostics, variants, Epitopes, Cohort, T cell, Convalescent patients, COVID-19 vaccines, T cell responses, convalescent, information, epitope, T cell epitope, T cell response, immunodominant epitopes, Analysis, T cell epitopes, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, individual, help, web-based platform, cohorts, landscape, fraction, Immunological studies, immunodominant, immunological, tested, identify, majority, individuals, recorded, 【제목키워드】 T cells, Epitopes, epitope, platform, individual,