Thermoregulation is a homeostatic mechanism that is disrupted in some neurological diseases. Patients with multiple sclerosis (MS) are susceptible to increases in body temperature, especially with more severe neurological signs. This condition can become intolerable when these patients suffer febrile infections such as coronavirus disease-2019 (COVID-19). We review the mechanisms of hyperthermia in patients with MS, and they may encounter when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Finally, the thermoregulatory role and relevant adaptation to regular physical exercise are summarized.
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【저자키워드】 SARS-CoV-2, exercise, multiple sclerosis, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, CNS, Central Nervous System, COVID-19, coronavirus disease-2019, NO, Nitric Oxide, VEGF, Vascular endothelial growth factor, ROS, reactive oxygen species, Thermoregulation, PAMPs, pathogen-associated molecular patterns, eNOS, endothelial nitric oxide synthase, MS, multiple sclerosis, sweat gland, ANS Autonomic nervous system, APN, Adiponectin, EDHF, Endothelial-derived hyperpolarizing factor, NLRP3, NLR family pyrin domain containing 3, PACAP, Pituitary adenylate cyclase-activating polypeptide, PGs, Prostaglandins, PGE2, Prostaglandin E2, SNS, Sympathetic nervous system, TRPV-1, Transient receptor potential vanilloid type 1, VDP, Vascular-dilating prostanoids, VIP, Vasoactive intestinal peptide,
【저자키워드】 SARS-CoV-2, exercise, multiple sclerosis, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, CNS, Central Nervous System, COVID-19, coronavirus disease-2019, NO, Nitric Oxide, VEGF, Vascular endothelial growth factor, ROS, reactive oxygen species, Thermoregulation, PAMPs, pathogen-associated molecular patterns, eNOS, endothelial nitric oxide synthase, MS, multiple sclerosis, sweat gland, ANS Autonomic nervous system, APN, Adiponectin, EDHF, Endothelial-derived hyperpolarizing factor, NLRP3, NLR family pyrin domain containing 3, PACAP, Pituitary adenylate cyclase-activating polypeptide, PGs, Prostaglandins, PGE2, Prostaglandin E2, SNS, Sympathetic nervous system, TRPV-1, Transient receptor potential vanilloid type 1, VDP, Vascular-dilating prostanoids, VIP, Vasoactive intestinal peptide,