Abstract
Objectives: We aimed to prospectively describe the incidence and clinical spectrum of SARS-CoV-2 infection in immunocompromised paediatric patients in the UK.
Methods: From March 2020 to 2021 weekly questionnaires were sent to immunocompromised paediatric patients or their parents. Information, including symptom presentation and SARS-CoV-2 PCR test results, was collected from 1527 participants from 46 hospitals. Cross-sectional serology was investigated in February and March 2021.
Results: Until the end of September 2020, no cases were reported. From September 28th 2020 to March 2021 a total of 38 PCR-detected SARS-CoV-2 infections were reported. Of these, four children were admitted to hospital but none had acute severe COVID-19. Increasing age in association with immunodeficiency increased reporting of SARS-CoV-2 infection. Worsening of fever, cough, and sore throat were associated with participants reporting SARS-CoV-2 infection. Serology data included 452 unvaccinated participants. In those reporting prior positive SARS-CoV-2 PCR, there were detectable antibodies in 9 of 18 (50%). In those with no prior report of infection, antibodies were detected in 32 of 434 (7•4%).
Conclusions: This study shows SARS-CoV-2 infections have occurred in immunocompromised children and young people with no increased risk of severe disease. No children died.
Keywords: COVID-19; Children; Immunocompromised; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, children, Immunocompromised, 【초록키워드】 SARS-CoV-2, severe COVID-19, serology, antibody, SARS-COV-2 infection, hospital, Infection, immunodeficiency, Symptom, cough, hospitals, Fever, Immunocompromised, Reporting, age, incidence, questionnaire, SARS-CoV-2 infections, association, severe disease, sore throat, parents, Participants, increased risk, participant, increasing age, SARS-CoV-2 PCR test, positive SARS-CoV-2 PCR, SARS-CoV-2 PCR test results, occurred, died, reported, investigated, detectable, was collected, Increasing, paediatric patient, 【제목키워드】 severe COVID-19, increased risk,