Abstract A new variant named Omicron (B.1.1.529), first identified in South Africa, has become of considerable interest to the World Health Organization. This variant differs from the other known major variants, as it carries a large number of unusual mutations, particularly in the spinous process protein and receptor binding domains. Some specific mutation sites make it vaccine resistant, highly infectious, and highly pathogenic. The world fears that the Omicron variant could be even more harmful than the previous major variant, given that it has emerged amid fierce competition to trigger a new global pandemic peak as infections in South Africa rise. However, some epidemiological evidence has emerged that the Omicron variant may produce milder patient symptoms. We speculate if the virulence of the Omicron variant will diminish as transmissibility increases, thereby signaling the beginning of the end for the global COVID‐19 pandemic. Based on this view, we make recommendations for COVID‐19 mitigation in the present and future. However, it will take a few weeks to determine the true threat posed by the Omicron variant and we need to be fully prepared for future outbreaks, regardless of their severity. The Omicron variant is highly infectious and highly pathogenic, and some specific mutation sites mean that this variant may be resistant to the vaccine. Some epidemiological evidence has emerged showing that the Omicron variant may lead to milder symptoms in patients. Current vaccines may provide high protection against severe diseases caused by Omicron; therefore, to try to avoid all variants, vaccination and booster shots continue to be recommended.
【저자키워드】 COVID‐19, SARS‐CoV‐2, breakthrough infections, Omicron variant, mild cases, vaccine boosters,