Abstract
The outbreak of Coronavirus disease 2019 (COVID-19) has caused a global health crisis. Nevertheless, no antiviral treatment has yet been proven effective for treating COVID-19 and symptomatic supportive cares have been the most common treatment. Therefore, the present study was designed to evaluate the effects of propolis and Hyoscyamus niger L. extract in patients with COVID-19. This randomized clinical trial was conducted on 50 cases referred to Akhavan and Sepehri Clinics, Kashan university of medical sciences, Iran. Subjects were divided into two groups (intervention and placebo). This syrup (containing 1.6 mg of methanolic extract along with 450 mg of propolis per 10 mL) was administered three times a day to each patient for 6 days. The clinical symptoms of COVID-19 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus Hyoscyamus niger L. extract than the placebo group. However, the administration of syrup was not effective in the control of nausea and vomiting. In conclusion, syrup containing propolis and Hyoscyamus niger L. extract had beneficial effects in ameliorating the signs and symptoms of COVID-19 disease, in comparison with placebo groups.
Keywords: COVID-19; Hyoscyamus niger L.; propolis.
【저자키워드】 COVID-19, Propolis, Hyoscyamus niger L., 【초록키워드】 Treatment, coronavirus disease, randomized clinical trial, Coronavirus disease 2019, clinical trial, Propolis, Clinical symptoms, Intervention, Antiviral treatment, headache, abdominal pain, diarrhea, Health crisis, COVID-19 disease, Iran, Health, outbreak, symptomatic, Signs and symptoms, Fever, Patient, Placebo, disease, supportive care, administration, chest pain, Dizziness, referred to, nausea and vomiting, not effective, Hyoscyamus niger, Shortness of breath, sore throat, two groups, Medical Sciences, placebo group, clinical symptom, dry cough, nausea, symptoms of COVID-19, vomiting, treating COVID-19, syrup, Administered, Effect, effective, caused, conducted, reduced, two group, groups, evaluate the effect, patients with COVID-19, the placebo group, 【제목키워드】 Patient, acute respiratory syndrome, clinical symptom,