Abstract
Background: Following the high morbidity and mortality due to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections in New Orleans, Louisiana, we sought to assess progress toward herd immunity.
Methods: Ochsner Health employees and patients who volunteered for Abbott SARS-CoV-2 immunoglobulin G (IgG) antibody test between March 1 and May 1, 2020 were included. We estimated IgG prevalence and used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for variables associated with IgG test status.
Results: Of the 13,343 participants with IgG test results, 78.6% were women, 70.6% were non-Hispanic White, 21.1% non-Hispanic Black, 2.9% Hispanic Americans and 5.4% belonged to other races. Overall, 7.99% (95% CI: 7.53-8.45%) of the participants tested IgG positive. In age-, sex- and body mass index (BMI)-adjusted analyses, non-Hispanic Blacks were 2.7-times more likely to test positive than non-Hispanic Whites (OR=2.72; 95% CI: 2.33-3.19). Corresponding ORs (95% CIs) were 1.29 (0.84-1.99) for Hispanic Americans and 1.22 (0.85-1.75) for Other race/ethnicities. Compared to participants in administrative occupations, physician assistants (OR=7.14; 95% CI: 1.72-29.6) and therapists (OR=4.74; 95% CI: 1.49-15.03) were significantly more likely to have IgG antibodies while the association among nurses was not significant (OR=2.35; 95% CI: 0.96-5.77). Relative to 1.40, the test threshold for positivity, our measurements indicate a strong immune response (5.38±1.69), especially among those with a higher BMI.
Conclusions: SARS-COV-2 IgG antibodies were prevalent only in 8% of the participants. IgG prevalence was highest among non-Hispanic Blacks and participants with higher BMI but was lower among older participants.
Keywords: COVID-19; IgG antibodies; Non-Hispanic Blacks; Prevalence; SARS-COV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Prevalence, IgG antibodies, Non-Hispanic Blacks, 【초록키워드】 SARS-CoV-2, IgG, Immunity, Infection, Sex, body mass index, New Orleans, IgG antibody, Immunoglobulin, Patient, Logistic regression, morbidity and mortality, Antibody test, women, BMI, respiratory, threshold, Other, association, Hispanic, Odds ratio, Nurse, Abbott, IgG test, black, Older, Participants, not significant, 95% confidence interval, white, participant, relative, 95% CIs, assistant, positive, strong immune response, variable, prevalent, highest, tested, significantly more, analyses, American, 【제목키워드】 SARS-CoV-2, IgG, coronavirus 2, respiratory, employee, Level,