Abstract
Introduction: Coronavirus disease 2019 (COVID-19), a new disease that we do not know yet how to treat, is rapidly evolving and has forced us to stay indoors. Surprisingly, a broad range of symptoms has been reported since COVID-19 emergence. Individual variations in susceptibility to SARS-CoV-2 can be due to non-genetic and genetic factors. Alpha-1-antitrypsin deficiency (AATD) is an inherited condition that is associated with an increased risk of liver and lung diseases which may increase susceptibility to COVID-19 infection. At the same time, there could be a possibility of developing non-hereditary AATD.
Discussion: In addition to some evidence showing the role of vitamin D deficiency in COVID-19 pathology, it has been recognized that there is a biological link between AAT and vitamin D. Therefore, here we offer a new perspective that lower vitamin D levels in COVID-19 patients can cause acquired AATD that provide a condition with more disease severity and a higher risk of death. As a consequence, COVID-19 individuals with vitamin D deficiency may have a higher risk of morbidity and mortality.
Conclusion: Therefore, early vitamin D and AAT assessments and optimal interventions could be helpful to prevent severe COVID-19 outcomes.
Keywords: Alpha-1-antitrypsin deficiency; Coronavirus disease 2019(COVID-19); Vitamin D.
【저자키워드】 Vitamin D, Alpha-1-antitrypsin deficiency, Coronavirus disease 2019(COVID-19), 【초록키워드】 COVID-19, SARS-CoV-2, Coronavirus disease 2019, severe COVID-19, Vitamin D, susceptibility, disease severity, Genetic, Lung disease, Intervention, Symptom, outcomes, COVID-19 infection, Factors, death, morbidity and mortality, assessment, disease, liver, Evidence, COVID-19 patient, deficiency, higher risk, increased risk, Perspective, individual, vitamin D level, treat, COVID-19 pathology, offer, Prevent, individual variation, reported, addition, 【제목키워드】 risk, alpha-1-antitrypsin, deficiency,