Highlights • The COVID-19 emerged in Wuhan City and rapidly spread throughout China. • NLR exhibited the largest area under the curve, with the highest specificity and sensitivity. • Elevated NLR can be considered independent biomarkers for indicating poor clinical outcomes. Aim To accumulate evidence that indicated the key role played by virus-triggered inflammation in the 2019-novel coronavirus disease (COVID-19) which emerged in Wuhan City and rapidly spread throughout China. Methods Age, neutrophil(NEU)-to-lymphocyte (LYM) ratio (NLR), lymphocyte-to-monocyte (MON) ratio, platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP) of 93 patients with laboratory confirmed COVID-19 were investigated and compared. The receiver operating characteristic curve was applied to determine the thresholds for five bio-markers, and their prognostic values were assessed via the Kaplan–Meier curve and multivariate COX regression models. Results The median age was 46.4 years old, and 37cases were females. A total of 27.8% of patients had been to Wuhan, and 73.1% had contacted with people from Wuhan. Fever (83.8%) and cough (70.9%) were the two most common symptoms. Elevated NLR and age were significantly associated with illness severity. The binary logistic analysis identified elevated NLR (hazard risk [HR] 2.46, 95% confidence interval [CI] 1.98–4.57) and age (HR 2.52, 95% CI 1.65–4.83) as independent factors for poor clinical outcome of COVID-19. NLR exhibited the largest area under the curve at 0.841, with the highest specificity (63.6%) and sensitivity (88%). Conclusions Elevated age and NLR can be considered independent biomarkers for indicating poor clinical outcomes.
【저자키워드】 COVID-19, Neutrophil-to-lymphocyte ratio, age, Platelet-to-LYM ratio, Predictive, 【초록키워드】 coronavirus disease, Biomarker, risk, cough, Symptoms, clinical outcomes, Laboratory, Clinical outcome, Spread, China, sensitivity, specificity, Wuhan, Patient, threshold, characteristic, NLR, Evidence, Analysis, Illness severity, C-reactive protein (CRP, Logistic, Prognostic value, Factor, 95% CI, 95% confidence interval, city, median age, regression models, Kaplan–Meier, females, FIVE, independent, Result, highest, significantly, indicated, investigated, elevated, applied, exhibited, determine, COX, accumulate, virus-triggered inflammation, were assessed, 【제목키워드】 diagnostic, NLR, COVID-19 patient,