A key feature of post-polio syndrome (PPS) is progressive loss of muscle strength. In other chronic diseases systemic inflammation has been linked to muscle wasting. In this study plasma TNF-α, IL-6, IL-8, and leptin levels were significantly increased in PPS-patients compared to healthy controls. There was however no association between these raised systemic levels of inflammatory mediators and long-term decline in quadriceps strength or other clinical parameters. In conclusion, there is evidence for systemic inflammation in PPS, yet the relationship with clinical deterioration remains tenuous.
All Keywords
【저자키워드】 Cytokines, Muscle strength, Motor neurons/pathology, Postpoliomyelitis syndrome.,
【저자키워드】 Cytokines, Muscle strength, Motor neurons/pathology, Postpoliomyelitis syndrome.,