COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st of January 2021, with a minimum of 100 patients. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. PRISMA guidelines were followed. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included (age 17–87 years). The included studies defined long-COVID as ranging from 14 to 110 days post-viral infection. It was estimated that 80% of the infected patients with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). Multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care.
【저자키워드】 Health care, NEUROLOGY, Signs and symptoms, 【초록키워드】 COVID-19, Meta-analysis, SARS-CoV-2, fatigue, Infection, systematic review, rehabilitation, Symptom, headache, Symptoms, Prevalence, persistence, Dyspnea, Patient, Complication, Clinical management, age, long-COVID, preventive measures, Care, patients, 95% CI, Perspective, inclusion criteria, random-effects model, article, disorder, Effect, FIVE, initial, defined, identify, performed, reported, searched, infected patient, 【제목키워드】 Meta-analysis, systematic review, Effect,