We developed a SARS-CoV-2 spike subunit vaccine formulation containing dual TLR ligand liposome adjuvant. The vaccine-induced robust systemic neutralizing antibodies and completely protected mice from a lethal challenge. Two immunizations protected against lung injury and cleared the virus from lungs upon challenge. The adjuvanted vaccine also elicited systemic and local anti-Spike IgA which can be an important feature for a COVID-19 vaccine.
All Keywords
【저자키워드】 Adaptive immunity, adjuvants, 【초록키워드】 neutralizing antibody, Vaccine, COVID-19 vaccine, lung, Lung injury, virus, immunization, mice, IgA, SARS-CoV-2 spike, Ligand, Liposome, subunit, TLR, robust, elicited, systemic and local, 【제목키워드】 COVID-19 vaccine, receptor, development, Ligand, Liposome,
【저자키워드】 Adaptive immunity, adjuvants, 【초록키워드】 neutralizing antibody, Vaccine, COVID-19 vaccine, lung, Lung injury, virus, immunization, mice, IgA, SARS-CoV-2 spike, Ligand, Liposome, subunit, TLR, robust, elicited, systemic and local, 【제목키워드】 COVID-19 vaccine, receptor, development, Ligand, Liposome,