OBJECTIVES: In this ancillary analysis of a multicenter, double-blinded, randomized, placebo-controlled trial, we investigated the effect of a single high dose of vitamin D 3 on the length of hospital stay of patients with severe 25-hydroxyvitamin D deficiency and COVID-19. METHODS: The primary outcome was length of hospital stay, defined as the total number of days that patients remained hospitalized from the date of randomization until the date of hospital discharge. Secondary outcomes included serum levels of 25-hydroxyvitamin D, mortality during hospitalization, number of patients admitted to the intensive care unit, and number of patients who required mechanical ventilation. ClinicalTrials.gov: NCT04449718. RESULTS: Thirty-two patients were included in the study. The mean (SD) age was 58.5 (15.6) years, body mass index was 30.8 (8.6) kg/m 2 , and 25-hydroxyvitamin D level was 7.8 (1.6) ng/mL. No significant difference was observed in the median interquartile range of length of hospital stay between the vitamin D 3 group (6.0 [4.0-18.0] days) versus placebo (9.5 [6.3-15.5] days) (log-rank p =0.74; hazard ratio, 1.13 [95% confidence interval (CI), 0.53-2.40]; p =0.76). Vitamin D 3 significantly increased serum 25-hydroxyvitamin D levels in the vitamin D 3 group compared with that in the placebo group (between-group difference, 23.9 ng/mL [95% CI, 17.7-30.1]; p <0.001). CONCLUSIONS: A dose of 200.000 IU of vitamin D 3 did not significantly reduce the length of hospital stay of patients with severe 25-hydroxyvitamin D deficiency and COVID-19.
【저자키워드】 SARS-CoV-2, Pneumonia, immune system, acute respiratory disease, 【초록키워드】 COVID-19, High dose, Hospitalized, Mortality, randomization, intensive care, Vitamin D, mechanical ventilation, Hospitalization, 25-hydroxyvitamin D, outcome, Randomized, body mass index, placebo-controlled trial, Patient, age, Placebo, multicenter, Analysis, dose, Hospital stay, deficiency, confidence interval, interquartile range, Primary outcome, significant difference, Serum level, double-blinded, hazard ratio, hospital discharge, serum 25-hydroxyvitamin D, secondary, significantly increased, defined, significantly, investigated, remained, required, reduce, the median, the placebo group, 【제목키워드】 Vitamin D, Effect, Length, with COVID-19,