SARS-CoV-2 is the cause of COVID-19. It infects multiple organs including the respiratory tract and gut. Dynamic changes of regional microbiomes in infected adults are largely unknown. Here, we performed longitudinal analyses of throat and anal swabs from 35 COVID-19 and 19 healthy adult controls, as well as 10 non-COVID-19 patients with other diseases, by 16 S rRNA gene sequencing. The results showed a partitioning of the patients into 3-4 categories based on microbial community types (I-IV) in both sites. The bacterial diversity was lower in COVID-19 patients than healthy controls and decreased gradually from community type I to III/IV. Although the dynamic change of microbiome was complex during COVID-19, a synchronous restoration of both the upper respiratory and gut microbiomes from early dysbiosis towards late more diverse status was observed in 6/8 mild COVID-19 adult patients. These findings reveal previously unknown interactions between upper respiratory and gut microbiomes during COVID-19. Rong Xu, Renfei Lu, Tao Zhang, Qunfu Wu, and colleagues perform a longitudinal analysis of throat and gut microbiomes on adult COVID-19 patients. They find initially lower bacterial diversity in COVID-19 patients, but demonstrate a restoration of microbiome diversity throughout disease progression for patients with mild forms of the disease.
【저자키워드】 SARS-CoV-2, viral infection, Prognostic markers, Microbiome, 【초록키워드】 COVID-19, Sequencing, Disease progression, Patient, Community, Mild, anal swab, respiratory tract, synchronous, change, microbial community, COVID-19 patients, rRNA, Bacterial, longitudinal analysis, Interaction, COVID-19 patient, Gut, other diseases, healthy control, type I, complex, COVID-19 adult patients, adult COVID-19 patients, dynamic, infect, controls, upper respiratory, performed, healthy, the patient, the disease, form, category, multiple organ, non-COVID-19 patient, 【제목키워드】 COVID-19, association, Gut, upper respiratory, Course, Temporal, bacterial microbiome,