[[[ Objective: ]]] We hypothesize that maternal transplacentally acquired antibodies may cause Attention Deficit/Hyperactivity Disorder (ADHD) symptoms years after birth, and tested the hypothesis in twins discordant for ADHD symptoms. [[[ Method: ]]] In a pre-screened sample of 7793 same sex twin pair’s (4-18 years) questionnaire data on hyperactivity and inattention was collected. Blood samples taken 5 days after birth from 190 ADHD-score discordant pairs (15% MZ) were analyzed for antibodies. [[[ Results: ]]] Pneumococcus Polysaccaride 14 (PnPs14) was present in the ADHD high scoring twin more often than in the lower scoring twin (P=0.04). [[[ Conclusion: ]]] Although the study provides no strong support for the hypothesis, infection or immunological factors may be one among several causes of ADHD. The genetic control obtained in a twin design may reduce the exposure contrast and a larger sample is needed to further explore the role of PnPs14 in the etiology of ADHD.
Twin study on transplacental-acquired antibodies and attention deficit/hyperactivity disorder — A pilot study
태반을 통해 획득된 항체와 주의력 결핍/과잉 행동 장애에 관한 쌍둥이 연구 — 파일럿 연구
[Category] 폐렴구균 감염증,
[Article Type] journal-article
[Source] pubmed
All Keywords