Abstract
(1) Background: Cardiopulmonary and brain functions are frequently impaired after COVID-19 infection. Exercise rehabilitation could have a major impact on the healing process of patients affected by long COVID-19. (2) Methods: The COVID-Rehab study will investigate the effectiveness of an eight-week cardiopulmonary rehabilitation program on cardiorespiratory fitness (V˙O 2 max) in long-COVID-19 individuals. Secondary objectives will include functional capacity, quality of life, perceived stress, sleep quality (questionnaires), respiratory capacity (spirometry test), coagulation, inflammatory and oxidative-stress profile (blood draw), cognition (neuropsychological tests), neurovascular coupling and pulsatility (fNIRS). The COVID-Rehab project was a randomised clinical trial with two intervention arms (1:1 ratio) that will be blindly evaluated. It will recruit a total of 40 individuals: (1) rehabilitation: centre-based exercise-training program (eight weeks, three times per week); (2) control: individuals will have to maintain their daily habits. (3) Conclusions: Currently, there are no specific rehabilitation guidelines for long-COVID-19 patients, but preliminary studies show encouraging results. Clinicaltrials.gov ( NCT05035628 ).
Keywords: COVID-19; cognition; exercise; long COVID; physical activity; rehabilitation; respiratory rehabilitation.
【저자키워드】 COVID-19, exercise, physical activity, rehabilitation, Long COVID, Cognition, respiratory rehabilitation, 【초록키워드】 Perceived stress, clinical trial, randomised, Cardiopulmonary, spirometry, Brain, Coagulation, COVID-19 infection, Patient, Effectiveness, Quality of life, patients, function, Inflammatory, sleep quality, Questionnaires, Neurovascular, individual, intervention arm, cardiorespiratory, blood draw, physical, affected, include, evaluated, eight, functional, maintain, individuals, 1:1, recruit, Secondary objective, 【제목키워드】 persistent,