Leprosy is the major cause of non-traumatic neuropathy. Herein, we investigated the role of ninjurin 1, an adhesion molecule involved in nerve regeneration in leprosy. Our results demonstrated that M. leprae stimulates in vitro up-regulation of ninjurin mRNA in cultured Schwann and blood cells as well as in vivo mRNA and protein expression in leprosy nerve biopsies. A polymorphism (asp110ala) was investigated in a case-control study (1123 individuals) and no association was found with leprosy per se or with disseminated forms. Nevertheless, ala110 was associated with functional nerve impairment (OR=2.42; p=0.02 for ala/ala) and with lower mRNA levels. Our data suggests that asp110ala could be a valuable genetic marker of nerve damage in leprosy.
Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage
닌주린 1 asp110ala 단일 염기 다형성은 나병 신경 손상에 대한 보호와 관련이 있습니다.
[Category] 한센병,
[Article Type] journal-article
[Source] pubmed
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