This study evaluated effects of the inducible nitric oxide synthase (iNOS) inhibitor, aminoguanidine (AG), on the neuropathology and clinical disease produced by Theiler’s murine encephalomyelitis virus (TMEV) DA strain infection. Treatment with AG was started on day 7, 14, 28 or 66 post-inoculation and continued for a minimum of 21 days. Inflammation, demyelination and axonal necrosis were scored in a blinded fashion on spinal cord sections from each mouse. Reduction in inflammation, demyelination and axonal necrosis was observed in mice treated with AG. Apoptosis within the spinal cord parenchyma and perivascular cuffs was significantly decreased. AG treatment resulted in delayed onset of clinical disease.
Nitric oxide synthase inhibitor, aminoguanidine, reduces inflammation and demyelination produced by Theiler’s virus infection
질산화산소 합성효소 억제제인 아미노구아니딘은 타일러 바이러스 감염으로 인한 염증과 탈수초화를 감소시킨다.
[Category] 폴리오,
[Article Type] journal-article
[Source] pubmed
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