Abstract
Background: Since July 13, 2021, a third SARS-CoV-2 vaccine BNT162b2 was approved in Israel to immunocompromised and seniors 60 years of age or older. We aimed to evaluate vaccine’s reactogenicity.
Methods: A retrospective cohort, using electronic surveys sent to booster vaccine recipients, during July 20-August 10, 2021.
Results: 17,820 participated in the survey, with a response rate of 30.2%. 3195 (17.9%) were immunocompromised. Fatigue, myalgia and fever were the most frequent systemic side effects reported (19.6%, 9.2% and 8.1% respectively among immunocompromised; 21.3%, 9.9% and 9.2% respectively among seniors). 67.3% of immunocompromised and 62% of seniors reported experiencing a better or a similar response to the third dose, compared to the second.
Conclusions: Local and systemic reactions after third BNT162b2 vaccine, reported by immunocompromised and seniors, were similar to those observed following previous vaccines and mostly self-resolved. These findings may aid promoting confidence among vaccine providers and recipients.
Keywords: Booster; Elderly; Immunocompromised; SARS-CoV-2; Side-effects; Vaccine.
【저자키워드】 SARS-CoV-2, Vaccine, elderly, Immunocompromised, booster, Side-effects, 【초록키워드】 Vaccine, BNT162b2 vaccine, reactogenicity, SARS-CoV-2 vaccine, BNT162b2, Fever, age, Booster vaccine, dose, myalgia, Older, systemic reaction, recipients, retrospective cohort, evaluate, reported, approved, participated, systemic side effect, 【제목키워드】 COVID-19 vaccine, BNT162b2 mRNA, immunocompromised individual,