Plasmodium falciparum thioredoxin reductase ( Pf TrxR) has been identified as a potential drug target to combat growing antimalarial drug resistance. Medicines for Malaria Venture (MMV) has pre-screened and identified a set of 400 antimalarial compounds called the Malaria Box. From those, we have evaluated their mechanisms of action through inhibition of Pf TrxR and found new active chemical scaffolds. Five compounds with significant Pf TrxR inhibitory activity, with IC 50 values ranging from 0.9–7.5 µM against the target enzyme, were found out of the Malaria Box.
All Keywords
【저자키워드】 antimalarial, malaria box, Plasmodium falciparum thioredoxin reductase, screening for mechanism of action,
【저자키워드】 antimalarial, malaria box, Plasmodium falciparum thioredoxin reductase, screening for mechanism of action,