Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite’s actinomyosin-based motor. Here we review the latest in our understanding of the molecular composition of this highly complex and fascinating biological process.
All Keywords
【저자키워드】 malaria, Invasion, Plasmodium, erythrocyte, Vivax, Merozoite, Falciparum,
【저자키워드】 malaria, Invasion, Plasmodium, erythrocyte, Vivax, Merozoite, Falciparum,