Objective We aimed to characterize the effects of prone positioning on respiratory mechanics and oxygenation in invasively ventilated patients with SARS-CoV-2 ARDS. Results This was a prospective cohort study in the Intensive Care Unit (ICU) of a tertiary referral centre. We included 20 consecutive, invasively ventilated patients with laboratory confirmed SARS-CoV-2 related ARDS who underwent prone positioning in ICU as part of their management. The main outcome was the effect of prone positioning on gas exchange and respiratory mechanics. There was a median improvement in the PaO 2 /FiO 2 ratio of 132 in the prone position compared to the supine position (IQR 67–228). We observed lower PaO 2 /FiO 2 ratios in those with low (< median) baseline respiratory system static compliance, compared to those with higher (> median) static compliance ( P < 0.05). There was no significant difference in respiratory system static compliance with prone positioning. Prone positioning was effective in improving oxygenation in SARS-CoV-2 ARDS. Furthermore, poor respiratory system static compliance was common and was associated with disease severity. Improvements in oxygenation were partly due to lung recruitment. Prone positioning should be considered in patients with SARS-CoV-2 ARDS.
【저자키워드】 severe acute respiratory syndrome coronavirus 2, Respiratory distress syndrome, Adult, Prone position, 【초록키워드】 ARDS, prone, disease severity, intensive care unit, outcome, prospective cohort study, ICU, Laboratory, improvement, management, Gas exchange, Respiratory system, Supine position, Oxygenation, prone positioning, Respiratory mechanics, no significant difference, lung recruitment, SARS-CoV-2 ARDS, static compliance, tertiary referral centre, Effect, objective, effective, Result, median, baseline, improving oxygenation, invasively ventilated patient, IQR, PaO, patients with SARS-CoV-2, 【제목키워드】 prone, cohort study, acute respiratory distress, Oxygenation, lung recruitment, IMPROVE, consecutive patient, patients with SARS-CoV-2,