Background A new coronavirus disease 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of patients may have difficulty in generating IgM or IgG antibodies against SARS-CoV-2, and little attention has been paid to them. Case presentations We present two cases of confirmed COVID-19 patients and characterize their initial symptoms, chest CT results, medication, and laboratory test results in detail (including RT-PCR, IgM/ IgG, cytokine and blood cell counts). Conclusion Both of patients with confirmed COVID-19 pneumonia failed to produce either IgM or IgG even 40 to 50 days after their symptoms onset. This work provides evidence demonstrating that at least a small proportion of patients may have difficulty in rapidly gaining immunity against SARS-CoV-2.
【저자키워드】 COVID-19, IgG, IgM, Case report, Negative antibodies results, 【초록키워드】 SARS-CoV-2, pandemic, Immunity, Pneumonia, cytokine, RT-PCR, Laboratory, IgG antibody, Chest CT, outbreak, Patient, medication, disease, New coronavirus, Evidence, COVID-19 patient, initial symptoms, symptoms onset, blood cell counts, Wuhan, China, proportion, provide, 【제목키워드】 antibody, COVID-19 confirmed patient,