Background Previous reports have described hypogonadism associated with virus infection such as hantavirus, human immunodeficiency virus (HIV) or severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). However, to our best knowledge there has been no case report of secondary hypogonadism following hand, foot, and mouth disease (HFMD). Case presentation A previously healthy 28-year-old man with no history of major physical and psychological trauma, presented with bilateral gynecomastia and erectile dysfunction 2 weeks after HFMD. Laboratory testament showed the level of gonadotropin hormones declined. Imaging examination demonstrated no major abnormal change in pituitary or reproductive system. The diagnosis of hypogonadism was established. Then the patient was ordered to maintain mental health outward of hospital without drug intervention. One month after presentation, his gonadotropin hormone level and sexual desire had recovered, while bilateral gynecomastia and erectile dysfunction symptoms disappeared. Conclusions Physicians should notice the possibility for hypogonadism in adult patients with a recent history of HFMD. Supplementary Information The online version contains supplementary material available at 10.1186/s12879-022-07030-0.
【저자키워드】 Case report, hypogonadism, Hand-foot-mouth disease, Adult-onset, 【초록키워드】 HIV, coronavirus, mental health, knowledge, hospital, Diagnosis, Intervention, Symptom, imaging, Patient, hormone, Psychological, virus infection, Human immunodeficiency virus, disease, trauma, dysfunction, Pituitary, acute respiratory syndrome, supplementary material, physician, physical, described, healthy, the patient, demonstrated, maintain, reproductive, declined, gynecomastia, 【제목키워드】 disease, secondary hypogonadism,