This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.
All Keywords
【저자키워드】 Vaccine, drug delivery, RNA, replicon, self-amplifying RNA, 【초록키워드】 Lipid nanoparticle, Clinical data, FIVE, reported, required, 【제목키워드】 mRNA, development,
【저자키워드】 Vaccine, drug delivery, RNA, replicon, self-amplifying RNA, 【초록키워드】 Lipid nanoparticle, Clinical data, FIVE, reported, required, 【제목키워드】 mRNA, development,