Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4^{+} T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by translocating effectors of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (T3SS) into host cells. In this review, we discuss processes that are hijacked by SPI-2 T3SS effectors and how this affects DC biology and the activation of T cell responses.
All Keywords
【저자키워드】 T cells, dendritic cells, Migration, Antigen presentation, Salmonella, T cell culling,
【저자키워드】 T cells, dendritic cells, Migration, Antigen presentation, Salmonella, T cell culling,