Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk predictors is limited. A retrospective analysis was performed in a German high-volume lung transplant center between 19 th March 2020 and 18 th May 2021. Impact of COVID-19 on physical and psychological health, clinical outcomes, and mortality were analyzed including follow-up visits up to 12 weeks after infection in survivors. Predictive parameters on survival were assessed using univariate and multivariate proportional hazards regression models. Out of 1,046 patients in follow-up, 31 acquired COVID-19 during the pandemic. 12 of 31 (39%) died and 26 (84%) were hospitalized . In survivors a significant decline in exercise capacity (p = 0.034), TLC (p = 0.02), and DLCO (p = 0.007) was observed at follow-up after 3 months. Anxiety, depression, and self-assessed quality of life remained stable. Charlson comorbidity index predicted mortality (HR 1.5, 1.1–2.2; p = 0.023). In recipients with pre-existing CLAD, mortality and clinical outcomes were inferior. However, pre-existing CLAD did not predict mortality. COVID-19 remains a life-threatening disease for lung transplant recipients, particularly in case comorbidities. Further studies on long term outcomes and impact on pre-existing CLAD are needed.
【초록키워드】 COVID-19, Treatment, pandemic, Depression, Hospitalized, Mortality, knowledge, Infection, Comorbidities, Exercise capacity, lung, Comorbidity, risk, outcome, clinical outcomes, Clinical outcome, outcomes, infections, survival, Survivors, Impact, Patient, Retrospective analysis, Quality of life, Follow-up, predictor, disease, predict, lung transplant, psychological health, recipients, hazard, life-threatening, regression models, recipient, patient population, survivor, parameter, Follow-up visit, physical, predicted, analyzed, died, remained, was performed, were assessed, 【제목키워드】 COVID-19, outcome, lung transplant,