Background Obesity has emerged as a risk factor for severe coronavirus disease 2019 (COVID-19) infection. To inform treatment considerations the relationship between obesity and COVID-19 complications and the influence of race, ethnicity, and socioeconomic factors deserves continued attention. Objective To determine if obesity is an independent risk factor for severe COVID-19 complications and mortality and examine the relationship between BMI, race, ethnicity, distressed community index and COVID-19 complications and mortality. Methods A retrospective cohort study of 1,019 SARS-CoV-2 positive adult admitted to an academic medical center (n = 928) and its affiliated community hospital (n-91) in New York City from March 1 to April 18, 2020. Results Median age was 64 years (IQR 52–75), 58.7% were men, 23.0% were Black, and 52.8% were Hispanic. The prevalence of overweight and obesity was 75.2%; median BMI was 28.5 kg/m 2 (25.1–33.0). Over the study period 23.7% patients died, 27.3% required invasive mechanical ventilation, 22.7% developed septic shock, and 9.1% required renal replacement therapy (RRT). In the multivariable logistic regression model, BMI was associated with complications including intubation (Odds Ratio [OR]1.03, 95% Confidence Interval [CI]1.01–1.05), septic shock (OR 1.04, CI 1.01–1.06), and RRT (OR1.07, CI 1.04–1.10), and mortality (OR 1.04, CI 1.01–1.06). The odds of death were highest among those with BMI ≥ 40 kg/m 2 (OR 2.05, CI 1.04–4.04). Mortality did not differ by race, ethnicity, or socioeconomic distress score, though Black and Asian patients were more likely to require RRT. Conclusions and relevance Severe complications of COVID-19 and death are more likely in patients with obesity, independent of age and comorbidities. While race, ethnicity, and socioeconomic status did not impact COVID-19 related mortality, Black and Asian patients were more likely to require RRT. The presence of obesity, and in some instances race, should inform resource allocation and risk stratification in patients hospitalized with COVID-19.
【초록키워드】 COVID-19, Treatment, SARS-CoV-2, Mortality, severe COVID-19, obesity, hospital, Infection, Comorbidities, intubation, risk factor, New York City, Prevalence, risk stratification, Patient, death, Septic shock, Community, Complication, age, BMI, resource, Hispanic, renal replacement therapy, Invasive mechanical ventilation, distress, confidence, retrospective cohort study, Asian, black, RRT, Socioeconomic factor, severe coronavirus disease, multivariable logistic regression, study period, independent risk factor, Median BMI, positive, COVID-19 related mortality, complications of COVID-19, while, over, men, objective, independent, Result, highest, not differ, required, determine, instance, interval, Ratio, COVID-19 complication, IQR, patients died, patients hospitalized, patients with obesity, with COVID-19, 【제목키워드】 Hospitalized, Mortality, Septic shock, complications, renal, patient cohort, with COVID-19,