Background Persons living with human immunodeficiency virus (PLWH) constitute a vulnerable population in view of their impaired immune status. At this time, the full interaction between HIV and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been incompletely described. Objective The purpose of this study was to explore the impact of HIV and SARS-CoV-2 co-infection on mortality. Method We systematically searched PubMed and the Europe PMC databases up to 19 January 2021, using specific keywords related to our aims. All published articles on coronavirus disease 2019 (COVID-19) and HIV were retrieved. The quality of the studies was evaluated using the Newcastle–Ottawa Scale for observational studies. Statistical analysis was performed with Review Manager version 5.4 and Comprehensive Meta-Analysis version 3 software. Results A total of 28 studies including 18 255 040 COVID-19 patients were assessed in this meta-analysis. Overall, HIV was associated with a higher mortality from COVID-19 on random-effects modelling {odds ratio [OR] = 1.19 [95% confidence interval (CI) = 1.01–1.39], p = 0.03; I 2 = 72%}. Meta-regression confirmed that this association was not influenced by age ( p = 0.208), CD4 cell count ( p = 0.353) or the presence of antiretroviral therapy (ART) ( p = 0.647). Further subgroup analysis indicated that the association was only statistically significant in studies from Africa (OR = 1.13, p = 0.004) and the United States (OR = 1.30, p = 0.006). Conclusion Whilst all persons ought to receive a SARS-CoV-2 vaccine, PLWH should be prioritised to minimise the risk of death because of COVID-19. The presence of HIV should be regarded as an important risk factor for future risk stratification of COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, HIV, Coronavirus disease 2019, AIDS, 【초록키워드】 coronavirus disease, Meta-analysis, Stratification, review, coronavirus, Europe, Mortality, risk factor, database, observational studies, SARS-CoV-2 vaccine, Antiretroviral therapy, Co-infection, ART, age, scale, Human immunodeficiency virus, PLWH, association, Immune status, Interaction, Analysis, COVID-19 patient, risk of death, confidence interval, acute respiratory syndrome, subgroup analysis, article, objective, Comprehensive, Result, described, indicated, the United State, evaluated, was performed, searched, statistically significant, receive, CD4 cell, future risk, Person, PMC, random-effect, retrieved, were assessed, 【제목키워드】 coronavirus disease, Meta-analysis, Mortality, Human, systematic review, immunodeficiency virus,