There is a deep need for mortality predictors that allow clinicians to quickly triage patients with severe coronavirus disease 2019 (Covid-19) into intensive care units at the time of hospital admission. Thus, we examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-monocyte ratio (NMR) as predictors of in-hospital death at admission in patients with severe Covid-19. A total of 54 Mexican adult patients with Covid-19 that met hospitalization criteria were retrospectively enrolled, followed-up daily until hospital discharge or death, and then assigned to survival or non-survival groups. Clinical, demographic, and laboratory parameters were recorded at admission. A total of 20 patients with severe Covid-19 died, and 75% of them were men older than 62.90 ± 14.18 years on average. Type 2 diabetes, hypertension, and coronary heart disease were more prevalent in non-survivors. As compared to survivors, LNR was significantly fourfold decreased while NMR was twofold increased. LNR ≤ 0.088 predicted in-hospital mortality with a sensitivity of 85.00% and a specificity of 74.19%. NMR ≥ 17.75 was a better independent risk factor for mortality with a sensitivity of 89.47% and a specificity of 80.00%. This study demonstrates for the first time that NMR and LNR are accurate predictors of in-hospital mortality at admission in patients with severe Covid-19.
【저자키워드】 COVID-19, SARS-CoV-2, neutrophil, intensive care unit, monocyte, lymphocyte, mortality predictor, in-hospital death risk, 【초록키워드】 Efficacy, Mortality, diabetes, hypertension, sensitivity, specificity, survival, Survivors, clinical, Patient, death, Hospital admission, predictor, Admission, in-hospital mortality, NMR, Coronary heart disease, In-hospital death, Non-survivors, Older, clinician, severe coronavirus disease, average, hospital discharge, independent risk factor, men, laboratory parameter, prevalent, enrolled, predicted, examined, died, significantly, assigned, groups, Type, were recorded, hospitalization criteria, 【제목키워드】 Ratio,