Abstract We simulated 3 transmission modes, including close-contact, respiratory droplets and aerosol routes, in the laboratory. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be highly transmitted among naive human angiotensin-converting enzyme 2 (hACE2) mice via close contact because 7 of 13 naive hACE2 mice were SARS-CoV-2 antibody seropositive 14 days after being introduced into the same cage with 3 infected-hACE2 mice. For respiratory droplets, SARS-CoV-2 antibodies from 3 of 10 naive hACE2 mice showed seropositivity 14 days after introduction into the same cage with 3 infected-hACE2 mice, separated by grids. In addition, hACE2 mice cannot be experimentally infected via aerosol inoculation until continued up to 25 minutes with high viral concentrations. Severe acute respiratory syndrome coronavirus 2 can be highly transmitted among naive angiotensin-converting enzyme 2 mice via close-contact spreading by respiratory droplets. However, these mice cannot be experimentally infected through aerosol inoculation unless it is continued for 25 minutes with a high viral concentration.
【저자키워드】 SARS-CoV-2, aerosol, hACE2 transgenic mice, Transmission routes, close contact, Respiratory droplets, 【초록키워드】 coronavirus, Transmission, angiotensin-converting enzyme 2, hACE2, Laboratory, SARS-CoV-2 antibody, mice, seropositive, Concentration, acute respiratory syndrome, human Angiotensin-converting enzyme, viral concentrations, respiratory droplet, transmitted, addition, introduced, separated, 【제목키워드】 Human, droplet, coronavirus 2, respiratory,