The first wave of the COVID-19 pandemic collapsed the hospitals in Castile and Leon (Spain). An analysis of the clinical characteristics, drug therapies and principal outcome predictors in the COVID-19 hospitalized patients from 1 March to 31 May 2020 is presented through a population-based registry study. Hospital stay variables, ventilation mode data and clinical outcomes were observed. In Castile and Leon hospitals, 7307 COVID-19 patients were admitted, with 57.05% being male and a median of 76 years. The mortality rate was 24.43%, with a high incidence of severe acute respiratory syndrome (SARS) (14.03%) and acute kidney injury (AKI) (10.87%). The most used medicines were antibiotics (90.83%), antimalarials (42.63%), steroids (44.37%) and antivirals, such as lopinavir/ritonavir (42.63%). The use of tocilizumab (9.37%) and anti-SIRS (systemic inflammatory response syndrome) medicines (7.34%) were remarkable. Fundamentally, death occurred more likely over 65 years of age (OR: 9.05). In addition, the need for ventilation was associated with a higher probability of death (OR: 3.59), SARS (OR: 5.14) and AKI (OR: 2.31). The drug-use pattern had been modified throughout the COVID-19 first wave. Multiple factors, such as age, gender and the need for mechanical ventilation, were related to the worst evolution prognosis of the disease.
【저자키워드】 COVID-19, Treatment, SARS-CoV-2, Mortality, Clinical characteristics, Acute kidney injury, Severe acute respiratory syndrome, 【초록키워드】 Evolution, therapy, Prognosis, mechanical ventilation, Tocilizumab, antivirals, COVID-19 pandemic, hospital, Ventilation, Gender, Antibiotics, outcome, antimalarial, hospitals, Clinical outcome, Medicine, Probability, AKI, male, Spain, Factors, death, age, mortality rate, predictor, incidence, First wave, Analysis, COVID-19 patient, steroid, acute respiratory syndrome, syndrome, systemic inflammatory response, Multiple, occurred, addition, the disease, median, hospitalized patient, variables, 【제목키워드】 clinical, registry, profile,