Here, the authors show that TRIM28-mediated SUMOylation of SARS-CoV-2 NP is critical for its liquid-liquid phase separation (LLPS) property and subsequent inhibition of innate antiviral immunity. The peptide NSIP-III is applied to unleash such connection by interfering TRIM28 and NP interaction.
All Keywords
【저자키워드】 SARS-CoV-2, viral infection, SUMOylation,
【저자키워드】 SARS-CoV-2, viral infection, SUMOylation,