Protease inhibitors represent attractive antiviral agents against coronaviruses, however, current inhibitors show restricted efficiency which limits their use. Here, the authors develop covalent reversible peptidyl inhibitors with nitroalkene warheads, showing inhibition against main protease and human Cathepsin L, preventing viral infection in a cellular assay.
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【저자키워드】 Computational chemistry, Proteases, Drug discovery and development,
【저자키워드】 Computational chemistry, Proteases, Drug discovery and development,