Statement of Significance: Decoy receptors can be effective against infectious diseases once their gateway receptors are identified. In our report, we showed that ACE2-Fc and DPP4-Fc were able to inhibit pseudotyped SARS-CoV-2 and MERS-CoV variants. Therefore, antibody-like receptor traps can act as potential therapeutics for highly mutated viruses.
All Keywords
【저자키워드】 SARS-CoV-2, ACE2, MERS-CoV, DPP4, decoy receptors, immunoadhesins, Fc-fusion proteins, receptor traps,
【저자키워드】 SARS-CoV-2, ACE2, MERS-CoV, DPP4, decoy receptors, immunoadhesins, Fc-fusion proteins, receptor traps,