Recently, and considering the COVID-19 pandemic, there has been a growing consensus that the disinfection of surfaces contaminated with pathogenic viral particles is essential. Chemical disinfectant sprays are effective at preventing the spread of infectious human noroviruses (Hu-NoVs) in healthcare and public areas. We assessed the virucidal activity of slightly acidic electrolyzed water (SAEW) spray on fomite surfaces. A multivariate statistical assessment that combined a response surface methodology (RSM) and a Box–Behnken design (BBD) was performed to define the optimal parameters of, and correlations among, experimental conditions. Spraying SAEW disinfectant (oxidation-reduction potential: 1123 mV, pH range: 5.12, available chlorine concentration: 33.22 ppm) resulted in the successful decontamination of Hu-NoV, with a 4-log reduction in viral particles on polyvinyl chloride, stainless steel, ceramic tile, and glass surfaces. Our experimental data revealed optimized treatment conditions for decontaminating Hu-NoV GI.6 and GII.4, using the numerical multiple optimized method (spraying rate: 218 mL/min, spraying time: 4.9 s, spraying distance: 0.9 m). These findings offer significant insights for designing optimal strategic control practices to prevent infectious disease, particularly Hu-NoV, transmission.
【저자키워드】 optimization, human norovirus, response surface methodology, slightly acidic electrolyzed water, spray disinfection, 【초록키워드】 Treatment, COVID-19 pandemic, Transmission, Infectious disease, Spread, healthcare, virucidal, methodology, correlation, Chemical, Norovirus, chloride, Consensus, PPM, Acidic, pathogenic, offer, viral particle, parameter, Prevent, effective, statistical, was performed, condition, to define, reduction in, conditions, available chlorine, 【제목키워드】 activity, surface, efficient, solution, Sprayer,