Statement of Significance: A modular antibody platform leveraging VHH heavy-chain constructs derived from humanized synthetic libraries to rapidly generate tetravalent VHH-Fc-VHH bispecifics was developed to combat viruses like SARS-CoV-2 that exhibit rapid antigenic drift. This platform was utilized to discover new antibodies and iteratively develop neutralizing bispecifics as new SARS-CoV-2 variants arose.
All Keywords
【저자키워드】 neutralizing antibody, SARS-CoV-2, omicron, multivalent, avidity, VHH, synthetic library, tetravalent bispecific,
【저자키워드】 neutralizing antibody, SARS-CoV-2, omicron, multivalent, avidity, VHH, synthetic library, tetravalent bispecific,