Background: Data are lacking regarding predictors of quantification of neutralizing antibodies (nAbs) based on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 50% neutralization titer (NT 50 ) after a single dose of COVID-19 vaccine in hemodialysis (HD) patients. Methods: This prospective single-center study enrolled 200 HD patients and 82 healthy subjects to estimate antibodies against the SARS-CoV-2 viral spike protein 1 and receptor-binding domain after a first dose of a COVID-19 vaccine (ChAdOx1 or mRNA-1273), measured by enzyme-linked immunosorbent assay and applied spline-based generalized additive model regression analysis to predict NT 50 converted to international units. Results: After the first dose of ChAdOx1, multiple linear regression showed that age ( p = 0.011) and cardiothoracic ratio ( p = 0.002) were negatively associated with NT 50 . Older age (OR = 0.958, p = 0.052) and higher cardiothoracic ratio (OR < 0.001, p = 0.037) could predict negative humoral response (NT 50 < 35.13 IU/mL). NT 50 was lower in HD patients compared with healthy controls receiving ChAdOx1 (10.68 vs. 43.01 IU/m, p < 0.001) or mRNA-1273 (36.39 vs. 262.2 IU/mL, p < 0.001). ChAdOx1 elicited lower GMTs than mRNA-1273 in the HD cohort (10.68 vs. 36.39 IU/mL, p < 0.001) and in healthy controls (43.01 vs. 262.22 IU/mL, p < 0.001). Conclusion: High cardiothoracic ratio and old age could independently predict a decline in nAb titers in an HD cohort vaccinated with a single dose of ChAdOx1.
【저자키워드】 COVID-19 vaccine, Neutralizing antibodies, Hemodialysis, Effectiveness, clinical response, 【초록키워드】 neutralizing antibody, SARS-CoV-2, coronavirus, antibody, mRNA-1273, Cohort, International, Patient, age, predictor, quantification, ChAdOx1, patients, predict, single dose, NAb, Multiple linear regression, humoral, regression analysis, viral spike protein, acute respiratory syndrome, healthy control, first dose, domain, single-center study, neutralization titer, enzyme-linked immunosorbent, enrolled, receiving, applied, elicited, healthy subject, GMT, the SARS-CoV-2, 【제목키워드】 COVID-19, titer, assessment, Ratio,