Background: Patients with kidney failure are at an increased risk of progression to a severe form of coronavirus disease 2019 (COVID-19) with high mortality. The current analysis was aimed to assess the impact of renal failure on the severity of COVID-19 and identify the risk factors of the fatal outcome in this population. Methods: The analysis included patients from the SARSTer database, a national real-world study evaluating treatment for COVID-19 in 30 Polish centers. Data were completed retrospectively and submitted online. Results: A total of 2322 patients were included in the analysis. Kidney failure was diagnosed in 455 individuals (19.65%), of whom 373 presented moderate stage and 82 patients, including 14 dialysis individuals, presented severe renal failure. Patients with kidney failure were significantly older and demonstrated a more severe course of COVID-19. The age, baseline SpO 2 , the ordinal scale of 4 and 5, neutrophil and platelet count, estimated glomerular filtration rate, and C-reactive protein concentration as well as malignancy and arterial hypertension were the independent predictors of 28-day mortality in logistic regression analysis. Conclusions: Underlying kidney disease in patients with COVID-19 is among the leading factors associated with a higher risk of severe clinical presentation and increased mortality rate.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, Kidney failure, 【초록키워드】 coronavirus disease, neutrophil, 28-day mortality, progression, outcome, risk factor, database, dialysis, kidney, severity of COVID-19, Patient, Kidney disease, Platelet, age, moderate, patients, glomerular filtration rate, Analysis, malignancy, Arterial hypertension, Older, Factor, Logistic regression analysis, higher risk, increased risk, individual, high mortality, increased mortality, National, renal, Course, identify, significantly, diagnosed, demonstrated, submitted, individuals, baseline, C-reactive protein concentration, independent predictor, patients with COVID-19, treatment for COVID-19, 【제목키워드】 Impact, failure,