The course of SARS-CoV-2 infection ranges from asymptomatic to a multiorgan disease. In this observational study, we investigated SARS-CoV-2 infected subjects with defined outcomes, evaluating the relationship between viral load and single nucleotide polymorphisms of genes codifying for IFNλs (interferon). The study enrolled 381 patients with laboratory-confirmed SARS-CoV-2 infection. For each patient, a standardized form was filled including sociodemographic variables and clinical outcomes. The host’s gene polymorphisms (IFNL3 rs1297860 C/T and INFL4 rs368234815 TT/ΔG) and RtReal-Time PCR cycle threshold (PCR Ct) value on SARS-CoV-2 were assessed on nasal, pharyngeal or nasopharyngeal swabs. Higher viral loads were found in patients aged > 74 years and homozygous mutant polymorphisms DG in IFNL4 (adj-OR = 1.16, 95% CI = 1.01–1.34 and adj-OR = 1.24, 95% CI = 1.09–1.40, respectively). After adjusting for age and sex, a statistically significantly lower risk of hospitalization was observed in subjects with higher RtReal-Time PCR cycle threshold values (adj-OR = 0.95, 95% CI = 0.91, 0.99; p = 0.028). Our data support the correlation between SARS-CoV-2 load and disease severity, and suggest that IFNλ polymorphisms could affect the ability of the host to modulate viral infection without a clear impact on the outcome of COVID-19.
【저자키워드】 SARS-CoV-2, Viral load, single nucleotide polymorphisms, COVID-19 outcomes, IFNλs, 【초록키워드】 COVID-19, viral infection, Hospitalization, SARS-COV-2 infection, disease severity, polymorphism, interferon, risk, nasal, outcome, clinical outcomes, outcomes, PCR, Asymptomatic, Single nucleotide polymorphism, nasopharyngeal swabs, Patient, mutant, correlation, threshold, multiorgan disease, Support, 95% CI, subject, laboratory-confirmed SARS-CoV-2 infection, pharyngeal, threshold value, Sociodemographic, IFNL4, homozygous, significantly lower, IFNL3, variable, Host, Affect, PCR cycle, Course, enrolled, defined, investigated, modulate, age and sex, statistically, IFNλ, SARS-CoV-2 infected subject, were assessed, 【제목키워드】 load, IFNλ,