Acute respiratory distress syndrome is the primary cause of death in patients with coronavirus disease 2019 (COVID-19) pneumonia. Our study aims to determine the association between serum markers and mortality in COVID-19 patients with respiratory failure. This retrospective study was conducted in a tertiary care hospital in South Korea. Forty-nine patients with COVID-19, who required high flow nasal cannulation or mechanical ventilation from February 2020 to April 2021, were included. Demographic and laboratory data were analyzed at baseline and on Day 7 of admission. We found that serum creatinine, troponin, procalcitonin, and soluble interleukin-2 receptor (sIL-2R) at baseline were more elevated in the non-survivor group, but were not associated with mechanical ventilator use on Day 7. Older age, PaO 2 /FiO 2 ratio, lymphocyte and platelet counts, lactate dehydrogenase, IL-6, C-reactive protein, and sIL-2R on Day 7 were significantly associated with mortality. Delta sIL-2R (Day 7–Day 0) per standard deviation was significantly higher in the non-survivor group (adjusted hazard ratio 3.225, 95% confidence interval (CI) 1.151–9.037, p = 0.026). Therefore, sIL-2R could predict mortality in COVID-19 patients with respiratory failure. Its sustained elevation suggests a hyper-inflammatory state, and mirrors the severity of COVID-19 in patients with respiratory failure, thereby warranting further attention.
【저자키워드】 Coronavirus disease 2019, Respiratory failure, Mortality, soluble interleukin-2 receptor, 【초록키워드】 COVID-19, coronavirus disease, mechanical ventilation, Pneumonia, IL-6, hospital, Delta, C-reactive protein, procalcitonin, nasal, lactate dehydrogenase, Retrospective study, lymphocyte, serum, severity of COVID-19, Patient, mechanical ventilator, death, Platelet, age, receptor, demographic, South Korea, Admission, Care, predict, association, marker, distress, COVID-19 patient, serum creatinine, Standard deviation, 95% confidence interval, adjusted hazard ratio, laboratory data, syndrome, non-survivor, analyzed, significantly, Day, required, elevated, conducted, determine, significantly higher, sustained, baseline, PaO, patients with COVID-19, 【제목키워드】 COVID-19, respiratory, failure, Level,